Using 21st Century Science to Improve Risk-Related Evaluations
National Academies Press (Verlag)
978-0-309-45348-6 (ISBN)
Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.
Table of Contents
Front Matter
Summary
1 Introduction
2 Advances in Exposure Science
3 Advances in Toxicology
4 Advances in Epidemiology
5 A New Direction for Risk Assessment and Applications of 21st Century Science
6 Model and Assay Validation and Acceptance
7 Interpretation and Integration of Data and Evidence for Risk-Based Decision-Making
Appendix A: Biographical Information on the Committee on Incorporating 21st Century Science into Risk-Based Evaluations
Appendix B: Case Studies on Chemical Assessments
Appendix C: Case Studies on Site-Specific Assessments
Appendix D: Case Study on Assessment of New Chemistries
Appendix E: A Bayesian Example: Predicting DoseResponse Relationships from High-Throughput Data and Chemical Structure
1 Front Matter; 2 Summary; 3 1 Introduction; 4 2 Advances in Exposure Science; 5 3 Advances in Toxicology; 6 4 Advances in Epidemiology; 7 5 A New Direction for Risk Assessment and Applications of 21st Century Science; 8 6 Model and Assay Validation and Acceptance; 9 7 Interpretation and Integration of Data and Evidence for Risk-Based Decision-Making; 10 Appendix A: Biographical Information on the Committee on Incorporating 21st Century Science into Risk-Based Evaluations; 11 Appendix B: Case Studies on Chemical Assessments; 12 Appendix C: Case Studies on Site-Specific Assessments; 13 Appendix D: Case Study on Assessment of New Chemistries; 14 Appendix E: A Bayesian Example: Predicting DoseResponse Relationships from High-Throughput Data and Chemical Structure
Erscheinungsdatum | 26.03.2017 |
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Verlagsort | Washington |
Sprache | englisch |
Maße | 216 x 279 mm |
Themenwelt | Naturwissenschaften ► Biologie ► Ökologie / Naturschutz |
Sozialwissenschaften ► Politik / Verwaltung ► Staat / Verwaltung | |
ISBN-10 | 0-309-45348-8 / 0309453488 |
ISBN-13 | 978-0-309-45348-6 / 9780309453486 |
Zustand | Neuware |
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