Role of Capsaicin in Oxidative Stress and Cancer

Buch | Softcover

178 Seiten

2015 | 2013 ed.
Springer (Verlag)
978-94-017-8429-0 (ISBN)

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This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; involvement of mitochondrial respiratory chain in the production of ROS; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.

Reihe/Serie	Diet and Cancer ; 3
Zusatzinfo	IX, 178 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Schulbuch / Wörterbuch
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Zellbiologie
	Sozialwissenschaften
ISBN-10	94-017-8429-9 / 9401784299
ISBN-13	978-94-017-8429-0 / 9789401784290
Zustand	Neuware