Chromosomal Instability in Cancer Cells

B. Michael Ghadimi, Thomas Ried (Herausgeber)

Buch | Softcover

VII, 224 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2015
Springer International Publishing (Verlag)
978-3-319-34962-6 (ISBN)

Artikel merken

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

DNA Repair and Chromosomal Translocations.- CINcere modelling: What have mouse models for chromosome instability taught us ?.- Telomere Dysfunction, Chromosomal Instability and Cancer.- Genetic Instability and Disease Prognostication.- Causes of Chromosomal Instability.- Patterns of Chromosomal Aberrations in Solid Tumors.- Yeast as Models of Mitotic Fidelity.- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development.- Consequences of aneuploidy in cancer: transcriptome and beyond.

Erscheinungsdatum	21.11.2016
Reihe/Serie	Recent Results in Cancer Research
Zusatzinfo	VII, 224 p. 39 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	361 g
Themenwelt	Sachbuch/Ratgeber ► Natur / Technik ► Naturführer
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Schlagworte	aneuploidy • Cancer • Disease Outcome • DNA repair • Genomic instability
ISBN-10	3-319-34962-7 / 3319349627
ISBN-13	978-3-319-34962-6 / 9783319349626
Zustand	Neuware