Clinical Immunobiology (eBook)

Fritz H. Bach, Robert A. Good (Herausgeber)

eBook Download: PDF

2014 | 1. Auflage
330 Seiten
Elsevier Science (Verlag)
978-1-4832-1633-1 (ISBN)

Infos

Clinical Immunobiology, Volume 2 covers the advances in the field being made to apply bone marrow transplantation to the treatment of several diseases. This volume is divided into 11 chapters and begins with surveys of the clinical considerations of bone marrow transplantation. Considerable chapters are devoted to the application of this transplantation to the treatment of various diseases, including aplastic anemia, aregenerative pancytopenia, leukemia, uniformly fatal severe combined immunodeficiency diseases, and Wiskott-Aldrich syndrome. Other chapters examine the cellular engineering in the form of bone marrow and thymus transplantation. The remaining chapters consider the effects of exposure to excessive amounts of radiation or cytotoxic chemicals, as well as the hematopoietic failure based on malfunction of the complex process of normal hematological development and maintenance. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Inhalt

Front Cover 1
Clinical Immunobiology 4
Copyright Page 
5 
Table of Contents 6
List of Contributors 12
Preface 14
Contents of Volume 1 18
Chapter 1. Bone Marrow Transplantation 20
I. Introduction 21
II. Terminology 23
III. Technique 23
IV. Histocompatibility 24
V. Preparation of the Recipient 26
VI. Clinical Results 27
VII. Special Consideration According to Underlying Disease 30
VIII. Support for the Patient without Marrow Function 35
IX. Success or Failure of Engraftment 40
X. GVH Disease 40
XI. Immunological Status of Long-Term Survivors of Marrow Transplantation 43
XII. Infection following Engraftment 44
XIII. Nature of Tolerance 45
XIV. Antileukemic Effect (Adoptive Immunotherapy) 46
XV. Malignant Transformation of Donor Cells 47
XVI. A Look at the Future 48
References 49
Chapter 2. Bone Marrow Transplantation for Aplasias and Leukemias 52
I. The First Bone Marrow Grafts in Man after Irradiation Exposure 52
II. Experimental and Clinical Bone Marrow Graft in Leukemia after Irradiation Conditioning ( GVH versus GVL ) 53
III. Bone Marrow Graft in Aplasias and Leukemias after ALG Conditioning Split Lymphocyte Chimerism
IV. Bone Marrow Transplantation using a Combination of ALG and Cyclophosphamide 69
V. Experimental Research for New Means to Control GVH 71
References 79
Chapter 3. Bone Marrow and Thymus Transplants: Cellular Engineering to Correct Primary Immunodeficiency 82
I. Lymphoid System Development and the Concept of Two Interacting Immunity Systems 84
II. Correction of the DiGeorge Syndrome by Thymus Transplantation 90
III. Bone Marrow Transplants to Correct Immunodeficiency Diseases 96
IV. Bone Marrow Transplant to Correct SCID 98
V. Bone Marrow Transplant in Treating the Wiskott-Aldrich ( WA)Syndrome 100
VI. Aspiration as a Problem in SCID Patients Fully Reconstituted Immunologically by Bone Marrow Transplantation 105
VII. Efforts to Use Isolated Stem Cells for Immunological Reconstitution in SCID 106
VIII. Efforts to Use Bone Marrow Transplantation to Correct SCID When a Matched Sibling Donor Is Not Available 107
IX. Genetic Determination of Histocompatibility Characteristics in Men and Mice 111
X. Bone Marrow Transplantation to Correct SCID with a Donor Mismatched with Recipient at All HL-A SD Determinants but Matched at the LD Locus Controlling MLC 114
XI. Correction of Clq Deficiency by Marrow Transplantation in SCID 115
XII. Relationship of Successful Marrow Transplantations in Aregenerative Anemia and Leukemia to Transplantations Used in SCID 116
XIII. Correction of SCID by Fetal Liver Transplantation 117
XIV. New Experimental Observations Relevant to Cellular Engineering in Man 119
XV. Cellular Engineering and Common Diseases of Man 121
XVI. Cellular Engineering and Immunodeficiencies Based on DefectiveDevelopment of Biological Amplification Systems 122
XVII. Immunodeficiencies in Common Human Diseases—A Challenge for Cellular Engineering 124
XVIII. Nutritional Deprivation and Immunological Deficiency—A Possible Challenge for Cellular or Molecular Engineering 126
XIX. Aging and Cellular Engineering 126
Bibliography 127
Chapter 4. Selective Immunotherapy withTransfer Factor 134
I. Introduction 135
II. Early Beginnings—Viable Cells as Vehicles of TF 136
III. Histoincompatible Cell Transfer and Graft-versus-Host (GVH) Disease 138
IV. Viable Lymphocytes versus TFD for Immunotherapy 139
V. Later Developments—Availability of TFD 140
VI. The Scope of TFD for Immunological Reconstitution 141
VII. TFD Immunotherapy of Infectious Disease 143
VIII. Reconstitution of Congenital Immunodeficiency Diseases with TFD Therapy 149
IX. TFD and Cancer Immunotherapy 154
X. Immunotherapy with TF—Unresolved Questions 160
XI. Conclusion 168
References 169
Chapter 5. Transfer Factor 172
I. Introduction 173
II. Preparation of Transfer Factor 174
III. Evaluation of Cellular Immunity 176
IV- Technique of Transfor Factor Therapy and Prophylaxis of Infection 181
V. Wiskott-Aldrich Syndrome 182
VI. Mucocutaneous Candidiasis 184
VII. Combined Immunodeficiency Disease 185
VIII. Infectious Diseases 186
IX. Diseases of Unknown Etiology 186
X. Malignancy 187
XI. Adverse Reactions 188
XII. Specificity of Transfer 190
XIII. Potential Uses of Transfer Factor 191
XIV. Conclusion 193
References 194
Chapter 6. Transfer Factor Therapy in Immunodeficiencies 196
I. Introduction 197
II. Preparation of TF 198
III. Effects in Normal Subjects 200
IV. Effects in Immunodeficiencies 201
V. Effects on Clinical Manifestations 204
VI. Discussion 205
VII. Summary 207
References 208
Chapter 7. Immunological Surveillance: Pro and Con 210
I. Historical Introduction 210
II. Tumor Immunogenicity 212
Ill. Effects of Minimal Immunity on Nascent Tumors 214
IV. Experimental Alteration of the Immune Response 217
V. Experiments of Nature 219
VI. Miscellaneous Correlations 219
VII. Tumor Susceptibility and Phylogeny 220
VIII. General Conclusions 220
References 221
Chapter 8. Serology of Cancer 224
I. Serological Detection of Antigens Associated with Tumors of Experimental Animals 225
II. Serological Approaches to the Study of Viral Oncogenesis 230
III. Serological Detection of Antigens Associated with Human Cancer 237
IV. Conclusions 249
Bibliography 250
Chapter 9. The Role of Cell-Mediated Immunity in Control and Growth of Tumors 252
I. Introduction 252
II. Evidence That Immune Cells Play an Important Role in the Rejection of Tumors Containing TAA 253
III. Tests for Cell-Mediated Immunity 255
IV. Demonstration of Cell-Mediated Immunity to Animal Tumors Using in Vitro Techniques 258
V. Escape Mechanisms from Immunological Surveillance 261
VI. The "Unblocking" Phenomenon 266
VII. "Potentiating" and "Arming" Serum Effects 267
VIII. Cell Types Involved in Host Defense Reactions Against Cancer 268
IX. Demonstration of Cell-Mediated Immunity to Human Tumors 269
X. Possible Implications of Tumor Immunology for Cancer Prevention and Therapy 277
Xl. Conclusion 282
Acknowledgments 282
References 282
Chapter 10. Experimental Models of Tumor Immunotherapy 284
I. Nonspecific Stimulation of the Immune Apparatus 286
II. Active Specific Immunotherapy 289
III. Adoptive Transfer of Cell-Mediated Immunity 294
IV. Passive Immunotherapy 297
V. Passive Transfer of Immunological Mediators 298
VI. Antiblocking Immunotherapy 299
VII. Discussion 300
References 301
Chapter 11. Graft versus Leukemia 306
I. The Problem 306
II. Conceptual Considerations 307
III. The Treatment Model—Overview 308
IV. The Treatment Model—Dissected 310
V. Recent Experimental Results 320
VI. Clinical Implications? 323
VII. Summary 324
References 325
Subject Index 326

Produkt-Details

• Erscheint lt. Verlag: 28.6.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Allgemeinmedizin
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• ISBN-10: 1-4832-1633-0 / 1483216330
• ISBN-13: 978-1-4832-1633-1 / 9781483216331