Immunology in Clinical Medicine (eBook)

J. L. Turk (Autor)

eBook Download: PDF

2014 | 3. Auflage
280 Seiten
Elsevier Science (Verlag)
978-1-4831-8303-9 (ISBN)

Infos

Immunology in Clinical Medicine is an introduction to immunology in clinical medicine, with emphasis on immunological concepts underlying disease processes. The effect of drugs known to suppress immunological processes are considered especially in relation to whether they operate by really suppressing immunological processes or whether they have other actions. Comprised of 17 chapters, this book begins with an overview of the nature of the immune response, followed by a discussion on reactionS in the tissues mediated by humoral antibodies. The reader is then introduced to reactions in the tissues caused by the cell-mediated immune response; immunological processes in infective diseases; and the concept of autoimmunity and its relation to disease. Subsequent chapters focus on the immunology of diseases such as cancer, skin diseases, connective tissue diseases, and diseases of the intestinal tract, respiratory tract, liver, and amyloidosis. The final chapter is devoted to the role of the clinical immunologist in patient care and therapy. This monograph is intended for students and practitioners of clinical medicine.

Inhalt

Front Cover 1
Immunology in Clinical Medicine 4
Copyright Page 5
Table of 
6 
Foreword 8
Preface to the First Edition 10
Preface to the Second Edition 12
Chapter I. 
14 
1. Introduction 14
2. The Nature of Antigens 16
3. The Nature of the Immune Response 17
4. Immunological Tolerance 27
5. Theories as to the Nature of the Immune Response 28
Bibliography 35
Chapter II. 
37 
1. Passive Sensitization with Humoral Antibodies 37
2. Reactions Mediated by Anaphylactic Antibodies 39
3. The Arthus Reaction 43
4. Serum Sickness 47
Bibliography 55
Chapter III. Reactions in tiie Tissues Caused by the Cell-mediated 
57 
1. Microbial Allergies 57
2. Insect Bites 63
3. Chemical Contact Sensitiyity 64
3. Allograft (Homograft) Reaction 66
5. The Possible Role of the Cell-mediated Immune Reaction in Autoimmunity 67
6. Cellular immunity 68
Bibliography 72
Chapter IV. 
73 
Innate or Natural Immunity 74
Natural Antibodies 74
The Development of Immunity After Infection Immunity to Bacteria 76
BCG Vaccination Against Tuberculosis 77
The Immunological Spectrum in Chronic Infectious Diseases 78
Malaria and Trypanosomiasis 83
Helminthic Infections 85
Immune Mechanisms in Virus Infections 86
Bibliography 90
Chapter V. Immunological Deficiency Diseases: Abnormalities in Immunoglobulin Synthesis 91
A. Congenital Defects 92
B. Acquired Defects 96
Treatment of Immunological Deficiency Diseases 98
Complement Deficiency States 99
The Significance of Raised Levels of Immunoglobulins Monoclonal Rise in Immunoglobulins
Polyclonal Rise in Immunoglobulins 102
Chapter VI. The Concept of Autoimmunity and its Relation to Disease 104
Bibliography 116
Chapter VII. Immunosuppressive Agents 117
A. The Effects of Irradiation 117
B. Immunosuppressive Drugs 120
Specific Immunological Tolerance Induced by an Immunosuppressive Agent 131
Bibliography 132
Chapter VIII. 
133 
The Immunological Background of Allogeneic (Homologous) Graft Rejection 133
The Nature and Inheritance of the Antigens Involved in Allograft Rejection—the Possibility of Matching Donors and Recipients—HL-A Antigens 137
Bone marrow Transplantation—Graft versus Host Disease 139
Immunosuppression and Transplantation 140
The Use of "Immunological Enhancement" in avoiding Graft Rejection or "Graft versus Host'' Disease 143
Transplantation of the Liver and other Organs 144
Corneal Transplantation 145
Transplantation of Cartilage and Bone 146
Bibliography 147
Chapter IX. 
148 
Systemic Lupus Erythematosus 149
Rheumatoid Arthritis 154
Rheumatic Fever 158
Polyarteritis Nodosa 159
Diffuse Scleroderma 160
Sjögren's Disease 161
Bibliography 161
Chapter .. Immunological Processes in Diseases of the Kidney 162
The Experimental Production of Renal Disease 162
Nephritis in Animals Caused by Virus Infections 166
Human Renal Disease 168
The Role of Complement in Glomerulonephritis 170
The Use of Immunosuppressive Drugs in the Treatment of Chronic 
170 
Bibliography 171
Chapter XI. Skin Diseases 172
Comparison of the Lesions of the Skin Produced by Immunological Means in Experimental Animals and Those Developing in Man 172
The role of the systemic absorption of bacterial antigens in the production of cutaneous conditions of "unknown aetiology" 177
Chronic mucocutaneous candidiasis 178
Cutaneous lesions associated with the circulation of antigens derived from neoplastic tissues 179
Immunological reactions in the skin due to physical agents 179
Atopic eczema (atopic dermatitis) 180
Discoid lupus erythematosus 181
Autoantibodies in bullous diseases of the skin and Beh.et's syndrome 182
Bibliography 184
Chapter XII. Related Organ-specific Immunological Diseases—Thyroid, Adrenals, Parathyroids and Stomach 186
Diseases of the Thyroid Gland 186
Adrenal glands—Addison's disease 191
Hypoparathyroidism 192
Immunological disease of the stomach—pernicious anaemia 192
Bibliography 194
Chapter XIII. Diseases of the Intestinal Tract, Respiratory Tract, 
195 
Ulcerative Colitis and other Allergic Diseases of the Gastro-intestinal Tract 195
Diseases of the Respiratory Tract 197
The association of lung disease with rheumatoid arthritis and antinuclear factor 199
Goodpasture's syndrome 200
Sarcoidosis 200
Diseases of the Liver 203
Hepatitis-Associated Antigen 204
Amyloidosis 205
Bibliography 207
Chapter XIV. 
209 
Rhesus Haemolytic Disease of the Newborn 209
"Autoimmune" Haemolytic Anaemias 211
Drug Induced Haemolytic Anaemia 214
Thrombocytopenic Purpura 217
The Treatment of Autoimmune Haemolytic Anaemia and Thrombocytopenic 
218 
Bibliography 221
Chapter XV. Immunological Processes Affecting the Eye and 
222 
The Eye 222
Central Nervous System 228
Myasthenia gravis 236
Bibliography 237
Chapter XVI. The Immunology of Cancer 238
1. Immunological Changes in the Cancer Cells 238
2. The Immunological Reaction of the Body Against Tumours 241
3. Immunotherapy of Cancer 250
Bibliography 254
Chapter XVII. The Role of the Clinical Immunologist 255
The Investigation of Cell-mediated Immune Function 257
Investigation of Immunoglobulins and Humoral Antibodies 259
Detection of Autoimmune Phenomena 260
The Diagnosis of Immune-complex Diseases 261
Transplantation Immunology 261
Immunohaematology 262
The Role of the Clinical Immunologist in the Clinic and at the Bedside 262
The Training of a Clnical Immunologist 263
Index 266

Produkt-Details

• Erscheint lt. Verlag: 12.5.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Allgemeinmedizin
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• ISBN-10: 1-4831-8303-3 / 1483183033
• ISBN-13: 978-1-4831-8303-9 / 9781483183039