Immunogenetics (eBook)

Chella S. David, Gabriel S Panayi (Herausgeber)

eBook Download: PDF

2014 | 1. Auflage
416 Seiten
Elsevier Science (Verlag)
978-1-4831-6461-8 (ISBN)

Infos

Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.

Inhalt

Front Cover 1
Immunogenetics 4
Copyright Page 5
Table of Contents 10
Preface 6
Contributors 7
Chapter 1. Major histocompatibility complex genes and their role in autoimmune and infectious diseases 12
INTRODUCTION 12
DEVELOPMENT OF THE MAJOR HISTOCOMPATIBILITY COMPLEX (H-2) OF THE MOUSE 13
THE DEVELOPMENT OF THE MAJOR HISTOCOMPATIBILITY COMPLEX (HLA) OF MAN 16
POLYMORPHISM AND GENETIC ORGANIZATION OF MHC GENES 18
EXPERIMENTAL MURINE MODELS OF HUMAN DISEASE 21
References 28
Chapter 2. The human major histocompatibility complex (MHC) 37
INTRODUCTION 37
STRUCTURE OF HLA CLASS I MOLECULES 38
THE Tla REGION 39
CLASS II LOCI 39
SEROLOGY OF CLASS I AND CLASS II MOLECULES 40
TISSUE DISTRIBUTION OF CLASS I AND CLASS II MOLECULES 41
THE T/t LOCUS 41
BIOSYNTHESIS OF MHC ANTIGENS 41
POLYMORPHISMS IN THE MHC 42
IMMUNOLOGICAL FUNCTION AND MHC 43
ACQUIRED IMMUNODEFICIENCY SYNDROME 50
ASSOCIATION OF IMMUNOLOGICAL ABNORMALITIES AND HLA TYPE 50
SUMMARY 53
Acknowledgements 54
References 54
Chapter 3. Complement genes of the human major histocompatibility complex: implications for linkage disequilibrium and disease associations 61
STRUCTURAL VARIANTS OF FACTOR B (BF) 63
GENETIC POLYMORPHISM IN C2 65
GENETIC POLYMORPHISM IN C4 66
NUCLEOTIDE ANALYSIS OF COMPLEMENT GENES 71
LINKAGE RELATIONSHIPS OF COMPLEMENT GENETIC LOCI 72
MHC MARKERS IN DISEASE 84
SUMMARY 94
Acknowledgements 94
References 94
Chapter 4. Genetics of human immunoglobulins 103
TWO GENES - ONE POLYPEPTIDE CHAIN 103
GENETIC REARRANGEMENTS 104
ANTIBODY DIVERSITY 104
ALLELIC EXCLUSION 105
CHROMOSOMAL LOCALIZATION OF Ig GENES 105
ROLE OF Ig GENES IN MALIGNANCY 106
Ig ALLOTYPES 106
ROLE OF ALLOTYPES IN THE IMMUNE RESPONSE 110
ROLE OF ALLOTYPES IN DISEASES 112
INTERACTION OF MHC AND Ig ALLOTYPES IN IMMUNE RESPONSE AND DISEASES 113
Acknowledgements 115
References 115
Chapter 5. The spondoarthritides 121
INTRODUCTION 121
HLA, DISEASES AND ETHNIC GROUPS 124
SEGREGATION OF THE SPONDOARTHRITIDES 132
AETIOLOGY AND PATHOGENESIS 138
DIAGNOSTIC VALUE OF B27 DETERMINATIONS 143
CONCLUSIONS 144
References 144
Chapter 6. Genetic studies of rheumatoid arthritis 151
WHAT IS RHEUMATOID ARTHRITIS? 151
WHAT IS THE SIGNIFICANCE OF RHEUMATOID FACTOR? 152
CLASSICAL GENETIC STUDIES 153
HLA STUDIES 154
HLA-DR ANTIGENS IN FAMILIES 159
HLA-DR ANTIGENS, RHEUMATOID FACTOR AND DISEASE SEVERITY 159
HLA-DR ANTIGENS AND DRUG TOXICITY 161
IMMUNE RESPONSE GENE TO COLLAGEN 162
CONCLUSION 163
Acknowledgements 163
References 164
Chapter 7. Genetics of systemic lupus erythematosus 168
INTRODUCTION 168
ANIMAL MODELS 169
FAMILY STUDIES 170
COMPLEMENT AND SYSTEMIC LUPUS ERYTHEMATOSUS 171
ASSOCIATIONS OF HLA ANTIGENS WITH SYSTEMIC LUPUS ERYTHEMATOSUS 175
WHAT IS THE DISEASE SUSCEPTIBILITY GENE IN THE MHC? 179
CONCLUSION 180
Acknowledgements 181
References 181
Chapter 8. Immunogenetics of multiple sclerosis 188
EPIDEMIOLOGY OF MULTIPLE SCLEROSIS 188
PATHOPHYSIOLOGY OF MULTIPLE SCLEROSIS 192
SPINAL FLUID IN MULTIPLE SCLEROSIS 193
THE TARGET IN MULTIPLE SCLEROSIS 194
BLOOD LYMPHOCYTES IN MULTIPLE SCLEROSIS 194
GENETICS OF MULTIPLE SCLEROSIS 195
ANIMAL MODELS 206
SYNTHESIS AND DISCUSSION 207
References 211
Chapter 9. Autoimmune thyroid disease 218
INTRODUCTION 218
FEATURES OF AUTOIMMUNE THYROID DISEASE 218
HEREDITY IN AUTOIMMUNE THYROID DISEASE 219
LESSONS FROM ANIMAL MODELS 221
AUTOIMMUNE THYROID DISEASE IN JUVENILES AND THEIR FIRST-DEGREE RELATIVES 223
HLA AND AUTOIMMUNE THYROID DISEASE 225
ANALYSIS OF GENETIC MARKERS 229
SUMMARY 239
Acknowledgement 240
References 240
Chapter 10. T-cell clones 245
INTRODUCTION 245
CLONING STRATEGIES 245
CYTOLYTIC T-CELL CLONES 248
ANTIGEN-REACTIVE, PROLIFERATING T-CELL CLONES 250
FUNCTIONS OF CLONED T CELLS 252
LYMPHOKINE PRODUCTION BY CLONED T CELLS 255
CELL SURFACE ANTIGENS EXPRESSED BY CLONED T LYMPHOCYTES 256
T-CELL CLONES AND THE T-CELL RECEPTOR FOR ANTIGEN 259
SUMMARY 260
References 261
Chapter 11. Molecular immunology: genes of the major histocompatibility complex of the mouse 271
INTRODUCTION 271
CLASS I GENES 274
CLASS II GENES 290
CLASS III GENES 299
CONCLUSIONS 299
Acknowledgements 300
References 300
Chapter 12. Monoclonal antibodies of murine and human origin: their generation, characterization and use 307
INTRODUCTION 307
HISTORICAL PERSPECTIVE 308
GENERATION OF MONOCLONAL ANTIBODIES 311
IDENTIFICATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES 327
MONOCLONAL ANTIBODIES IN BIOMEDICAL RESEARCH AND THEIR CLINICAL APPLICATIONS 337
THE FUTURE OF MONOCLONAL ANTIBODIES 371
Acknowledgements 374
References 375
Index 412

Produkt-Details

• Erscheint lt. Verlag: 19.5.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Allgemeinmedizin
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• ISBN-10: 1-4831-6461-6 / 1483164616
• ISBN-13: 978-1-4831-6461-8 / 9781483164618