Antigens (eBook)

Volume V

Michael Sela (Herausgeber)

eBook Download: PDF

2014 | 1. Auflage
424 Seiten
Elsevier Science (Verlag)
978-1-4832-6957-3 (ISBN)

Infos

The Antigens, Volume V is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Four complex problems of direct relevance to human health are explored, namely, tumor antigens, antigens of helminths, cytotoxic lymphocytes, and complement. Comprised of four chapters, this volume begins with a review of classic studies of tumor-specific transplantation antigens, followed by a discussion on the detection and purification of tumor antigens; the immune response to tumor antigens; and the role of tumor antigens in the escape of tumors from immunological control. The reader is then introduced to some aspects of the different functions of antigens of helminths, along with the immune response in helminthiasis. The book also examines the generation, properties, and mode of action of antibody-independent cytolytic T lymphocytes before concluding with an analysis of the complement system and its reaction pathways as well as its role as an autoantigen. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Inhalt

Front Cover 1
The Antigens 4
Copyright Page 5
Table of Contents 6
List of Contributors 8
Preface 10
Contents of Other Volumes 12
CHAPTER 1. Tumor Antigens 16
I. Introduction 17
II. Classic Studies of Tumor-Specific 
18 
III. Detection of Tumor Antigens 21
IV. Purification of Tumor Antigens 29
V. Nature of Tumor Antigens 35
VI. The Immune Response to Tumor Antigens 49
VII. The Role of Tumor Antigens in the Escape 
54 
VIII. Human Tumor Antigens 62
IX. Conclusions 80
Acknowledgments 81
References 81
CHAPTER 2. Antigens of Helminths 98
I. Introduction 98
II. Immunity to Helminths 99
III. Pathophysiology of Antigens 120
IV. Applications: Immunodiagnosis and Immunoprevention 151
V. Concluding Remarks 167
Acknowledgments 171
References 171
CHAPTER 3. Cytotoxic Lymphocytes 188
I. Introduction 188
II. Assay of Lymphocyte-Mediated Cytotoxicity in Vitro 190
III. Cytolytic T Lymphocytes 200
IV. Antibody-Dependent Lymphocyte-Mediated Cytotoxicity 223
V. Natural Cytotoxicity Mediated by Lymphocytes 249
VI. Concluding Remarks 275
References 278
CHAPTER 4. Complement 298
I. Introduction 299
II. Complement Terminology 301
III. The Proteins of the Complement Sequence 303
IV. Components without Clear Homologue 312
V. The Reaction Mechanisms of Complement 313
VI. Reaction Mechanisms of the Terminal Portion 
331 
VII. Biosynthesis of Complement 336
VIII. The Biological Properties of the Complement System 338
IX. Complement as an Autoantigen 344
X. The Genetics of the Complement System 348
XI. Complement Components of Cell Membranes 358
XII. Complement in the Induction of the Antibody Response 359
References 362
Author Index 370
Subject Index 405

Produkt-Details

• Erscheint lt. Verlag: 10.5.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Natur / Technik ► Naturführer
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• ISBN-10: 1-4832-6957-4 / 1483269574
• ISBN-13: 978-1-4832-6957-3 / 9781483269573