Review of the Radiosensitivity of the Tissues in Bone (eBook)
44 Seiten
Elsevier Science (Verlag)
978-1-4831-8118-9 (ISBN)
Dr. Sam Stuart is a physiotherapist and a research Fellow within the Balance Disorders Laboratory, OHSU. His work focuses on vision, cognition and gait in neurological disorders, examining how technology-based interventions influence these factors. He has published extensively in world leading clinical and engineering journals focusing on a broad range of activities such as real-world data analytics, algorithm development for wearable technology and provided expert opinion on technology for concussion assessment for robust player management. He is currently a guest editor for special issues (sports medicine and transcranial direct current stimulation for motor rehabilitation) within Physiological Measurement and Journal of NeuroEngineering and Rehabilitation, respectively.
A Review of the Radiosensitivity of the Tissues in Bone is a report prepared by the Task Group for the International Commission on Radiological Protection Committees 1 and 2. The book reviews a biological indicator of the maximum permissible radiation dose. Data shows that an induction of malignant change should be considered as the limiting factor in maximum permissible levels for the bone. The risk of carcinogenesis in cells is connected with the proliferative potential of the cells. These cells are on bone marrow surfaces, in hematopoietic marrow, and in certain epithelial cells close to bone surfaces. The text also reviews the changes in the patterns of distribution resulting from growth and remodeling of bone. The book examines the effect of distribution of alkaline earth, of plutonium, of thorium, of americium, and of phosphorus in bone growth. The book also evaluates the comparative tumorigenic effects of external and internal irradiation of bone and the factors to be considered in determining the dose limitation from bone-seeking radionuclides. This book can prove beneficial to researchers and practitioners in the fields of radiology, internal medicine, or oncology.
Front Cover 1
A Review of the Radiosensitivety of the Tissues in Bone 2
Copyright Page 3
Table of Contents 4
PREFACE 6
INTRODUCTION 8
SECTION 1: THE LOCATION AND RELATIVE NUMBERS OF RADIOSENSITIVE CELLS AND OF CELLS NOT CONSIDERED TO BE RADIOSENSITIVE IN BONE AND IN BONE MARROW 10
A. Biological Indicator of Maximum Permissible Radiation Dose 10
B. The Cells at Carcinogenic Risk 11
SECTION 2: THE LOCALIZATION OF BONE-SEEKING RADIONUCLIDES AND THE IONIZATION PATTERNS RESULTING FROM THEIR DEPOSITION IN RELATION TO RADIOSENSITIVE CELLS OF BONE AND MARROW 14
A. Bone Distribution 14
B. Marrow Distribution 17
SECTION 3: CHANGES IN THE PATTERNS OF DISTRIBUTION RESULTING FROM GROWTH AND REMODELLING OF BONE 18
A. Alkaline Earths 18
B. Plutonium 18
C. Thorium 18
D. Americium 18
E. Phosphorus 18
SECTION 4: BIOLOGICAL DATA ON TUMOUR FORMATION AND DEGENERATIVE CHANGES 19
A. Tumour Formation 19
B. Degenerative Changes 25
SECTION 5: CONSIDERATION OF THE COMPARATIVE TUMORIGENIG EFFECTS OF EXTERNAL AND INTERNAL IRRADIATION OF BONE 25
A. Human Experience with External Irradiation 25
B. Human Experience with Internal Irradiation 28
C. Experimental Results with Animals 28
SECTION 6: FACTORS TO BE CONSIDERED IN DETERMINING THE DOSE LIMITATION FROM BONE-SEEKING RADIONUCLIDES 29
A. General Considerations 29
B. Available Data on some Bone-seeking Radionuclides 30
C. Possible New Approaches to the Setting of Dose Limits for Bone-seeking Radionuclides 33
SECTION 7: SUMMARY AND CONCLUSIONS 38
REFERENCES 39
| Erscheint lt. Verlag | 22.10.2013 |
|---|---|
| Sprache | englisch |
| Themenwelt | Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren |
| Medizin / Pharmazie ► Gesundheitsfachberufe | |
| Studium ► 2. Studienabschnitt (Klinik) ► Rechtsmedizin | |
| Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung | |
| Technik | |
| ISBN-10 | 1-4831-8118-9 / 1483181189 |
| ISBN-13 | 978-1-4831-8118-9 / 9781483181189 |
| Haben Sie eine Frage zum Produkt? |
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