Lung Circulation (eBook)

Physiology and Pharmacology

Domingo M. Aviado (Autor)

eBook Download: PDF

2013 | 1. Auflage
624 Seiten
Elsevier Science (Verlag)
978-1-4831-6557-8 (ISBN)

Infos

The Lung Circulation deals with important aspects of the lung circulation, with emphasis on the physiology of the pulmonary and bronchial circulation and autonomic pharmacology. Topics covered range from the role of anoxia in pulmonary circulation to reflexes arising from the pulmonary circulation and neighboring structures. The release of chemical substances from the pulmonary and bronchial circulation is also discussed. This volume is comprised of 10 chapters and begins with a review of the influence of anoxia on pulmonary circulation as well as four pertinent effects of anoxemia, namely, respiratory stimulation; cardiac stimulation; systemic vasoconstriction and vasodilatation; and pulmonary vasoconstriction and vasodilatation). The following chapters focus on the regulation of bronchial circulation; autonomic nervous control of pulmonary circulation involving acetylcholine, anticholinesterases, and atropine; and the pharmacology of sympathomimetic drugs, sympathetic blocking drugs, ganglion stimulants, and blocking drugs. The final chapter is devoted to the pharmacology of the autonomic nervous system and considers drugs that stimulate chemoreflexes arising from the lung circulation, including veratrum alkaloids. This book will appeal to physiologists and pharmacologists.

Inhalt

Front Cover 1
Physiology and Pharmacology 4
Copyright Page 5
Table of Contents 8
Dedication 6
ACKNOWLEDGEMENTS 10
INTRODUCTION 11
Volume I LIST OF CHAPTERS 14
Volume ILIST OF FIGURES 17
SECTION A: PHYSIOLOGY OF THE PULMONARY AND BRONCHIAL CIRCULATION 26
Chapter 1. Anoxia and the pulmonary circulation: systemic mechanisms 28
A. Hemodynamic effects of anoxia 34
B. Role of chemoreceptors in mediating hemodynamic effects of anoxia 58
C. The autonomic nervous system and the heart 80
D. Summary of anoxic effects on the pulmonary circulation 96
References 99
Chapter 2. Anoxia and the pulmonary circulation: mechanisms in the lung 109
A. Unilateral anoxia by bronchospirometry 110
B. Lung perfusion 113
C. Reactions of components of the lung circulation 125
D. Anoxia on the limb circulation 127
E. Summary of intrapulmonary mechanisms 137
References 140
Chapter 3. Reflexes arising from the pulmonary circulation and neighboring structures 145
A. Baroreceptors in the cardiopulmonary area 146
B. Chemoreceptors in the pulmonary circulation 180
C. Stretch receptors in the lung parenchyma 184
D. Functional significance of cardiopulmonary reflexes 188
References 199
Chapter 4. The bronchial circulation 210
A. Anatomical studies 211
B. Measurement of blood flow 218
C. Regulation of bronchial circulation 232
D. Alterations in blood oxygen content 246
E. Pathologic physiology of the bronchial circulation 254
References 269
Chapter 5. The release of chemical substances from the pulmonary and bronchial circulation 280
A. Histamine 281
B. 5-Hydroxytryptamine 300
C. Polypeptides and miscellaneous substances 320
D. Adenosine triphosphate and its release from erythrocytes 323
E. Significance of release of chemical substances 328
References 329
SECTION B: AUTONOMIC PHARMACOLOGY 
346 
Chapter 6. Autonomic nervous control of the pulmonary circulation acetylcholine, anticholinesterases and atropine
A. The autonomic nervous system 349
B. Acetylcholine and other parasympathomimetics 354
C. Anticholinesterases 366
D. Parasympathetic blockade: atropine 368
E. Significance of drugs acting on the parasympathetic nervous system 370
References 371
Chapter 7. Sympathomimetic drugs 380
A. Pulmonary vasoconstrictors 382
B. Pulmonary vasodilators 401
C. Miscellaneous sympathomimetics 429
References 453
Chapter 8. Sympathetic blocking drugs 469
A. Blockade by competitive inhibition 470
B. Predominant adrenolytic drugs 478
C. Sympathetic nerve blocking drugs 479
D. Beta receptor blockade 498
E. Miscellaneous drugs 504
References 507
Chapter 9. Ganglion stimulants and blocking drugs 520
A. Ganglion stimulating drugs 521
B. Ganglion blocking drugs 544
C. Significance of drugs acting on the autonomic ganglia 564
References 565
Chapter 10. Veratrum alkaloids and other drugs stimulating chemoreflexes 576
A. Veratrum alkaloids 577
B. Chemoreflexes arising from the lungs 592
C. Chemoreflexes arising from the heart and lungs 598
References 605

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-6557-4 / 1483165574
• ISBN-13: 978-1-4831-6557-8 / 9781483165578