Drugs in Cerebral Palsy (eBook)

Based on a Symposium Held at Dallas, 24-26 November, 1963

Eric Denhoff, Patrick Hume Kendall, Amedeo Marrazzi (Autoren)

eBook Download: PDF

2013 | 1. Auflage
96 Seiten
Elsevier Science (Verlag)
978-1-4832-2184-7 (ISBN)

Infos

Clinics in Developmental Medicine No. 16: Drugs in Cerebral Palsy: Based on a Symposium held at Dallas, 24-26 November, 1963 is a collection of papers of the 1963 Symposium on Drugs in Cerebral Palsy, arranged by the American Academy. This book is composed of nine chapters that cover the various components and treatment options involved in cerebral palsy. This text begins with a presentation of the many problems of drug evaluation, with an emphasis on the issue that human responses to a drug cannot be predicted from those of animals and that the response of one human to a drug may differ quite sharply from that of another. The next chapters deal with the historical developments and pharmacology of drugs in cerebral palsy, as well as the two aspects of drug evaluation, namely, the immediate or direct effects of the drug on patients and the double-blind test. The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. The last chapter considers the possible toxic drug reactions, which are the result of individual idiosyncrasy and may occur regardless of drug dosage. This book will be of value to pharmacologists, neurologists, clinicians, and researchers who are interested in drug evaluation in cerebral palsy.

Inhalt

Front Cover 1
Drugs in Cerebral Palsy: Based on a Symposium held at Dallas, 24-26 November, 1963 2
Table of Contents 6
Contributors 5
Preface 8
Chapter 1. Introduction 10
REFERENCES 11
Chapter 2. General Principles of Drug Evaluation 12
Pre-Clinical Studies 12
Clinical Evaluation 13
Phase 1 — Acute Human Pharmacology 13
Phase 2 — Exploratory Bioassay 14
Phase 3 — Controlled Study 15
REFERENCES 18
Chapter 3. Pharmacology of Drugs in Cerebral Palsy 19
The Problem 19
Cerebral Homeostasis 19
The Role of Gamma Aminobutyric Acid 23
Cerebral Synaptic Transmission and Behavioural State 23
Perception and Disturbed Cerebral Function 28
Conclusions 29
Outlook 30
REFERENCES 31
Chapter 4. The History of Drug Therapy in Cerebral Palsy 33
Anti-epileptic Drugs and Sedatives 34
Drugs Specifically Affecting Neuro-muscular Disorders 35
Muscle Relaxants 36
The Cerebral Palsied Patient and Drug Therapy 37
Chapter 5. Recording the Progress of Skills in Cerebral Palsy 38
REFERENCE 39
Appendix 43
Chapter 6. The Use of Muscle Relaxants in Cerebral Palsy 50
Assessment of Relaxants 51
Carisoprodol 54
Indications for Administration of Muscle Relaxants 58
Contra-indications 59
REFERENCES 60
Chapter 7. Anti-convulsant Drugs 61
The Drugs 61
REFERENCES 70
Chapter 8. Drugs, Behaviour and the Family 71
Behavioural Disorders in Cerebral Palsy 71
Diagnosis 72
Assessment of the Drugs 73
Amphetamine 74
Phenothiazine Derivatives. 77
Hypnotics 78
Appetiser 78
Vitamins 79
Hormones 80
REFERENCES 80
Chapter 9. Toxic Drug Reactions 81
REFERENCE 82
Drug Index 84
Trade Names with Reference to Generic Names 91

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-2184-9 / 1483221849
• ISBN-13: 978-1-4832-2184-7 / 9781483221847