Molecular Biology of Protein Folding, Part B (eBook)

P. Michael Conn (Herausgeber)

eBook Download: EPUB

2009 | 1. Auflage
288 Seiten
Elsevier Science (Verlag)
978-0-08-092339-0 (ISBN)

Infos

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

* Reviews the research and aids the reader in understanding the mechanisms of protein misfolding. This helps to understand diseases and guide researchers to design therapeutic strategies.
* Highlights important topics and presents a thorough review eliminating searching through many journal articles

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Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. - Follow the new editor-in-chief, P. Michael Conn, as he introduces this second thematic volume in the series an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding- Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer's and diabetes- Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

Inhalt

Front Cover 1
Molecular Biology and Translational Science 4
Copyright Page 5
Contents 6
Chapter 1: Self-Organizing Dynamics in Protein Folding 10
I. Introduction 11
II. Protein Structure and Folding 12
III. Self-Organization and Nonlinear Processes 16
IV. Self-Organization in Protein Folding 20
V. Summary 40
References 40
Chapter 2: Toward Reliable Simulations of Protein Folding, Misfolding and Aggregation 48
I. Introduction 48
II. Protein Models 49
III. Algorithms for Optimizing Protein Configurations 51
IV. Algorithms for Simulating the Thermodynamics of Configurations 52
V. Folding Simulations of Small Proteins 57
VI. Misfolding and Aggregation 59
VII. Conclusion 60
References 61
Chapter 3: Use of Protein Engineering Techniques to Elucidate Protein Folding Pathways 66
I. Introduction 67
II. Early Protein Engineering Studies of Folding Pathways 68
III. Single Point Mutations and Phi-Value Analysis 70
IV. Psi-Value Analysis 89
V. Proline Isomerization 91
VI. Repeat Proteins 92
VII. Circular Permutants 96
VIII. Multidomain Proteins 100
IX. Engineering Probes of Folding into Proteins 104
X. Single-Molecule Studies of Protein Folding Pathways 106
XI. Summary 109
References 110
Chapter 4: Principles of Protein Misfolding 124
I. Protein Folding and Misfolding 125
II. Protein Misfolding: Amyloid Diseases 145
III. Light Chain Amyloidosis 154
IV. Conclusions 160
References 161
Chapter 5: Protein Folding Revisited 170
I. Introduction 171
II. Perspectives on the Folding Problem 180
III. Wormholes in More Detail 195
IV. Conclusions 203
References 206
Chapter 6: Minimal Models for Proteins and RNA: From Folding to Function 212
I. Introduction 213
II. Rationale for Developing Structure-Based CG Models 215
III. Protein Folding 218
IV. RNA Folding 240
V. Concluding Remarks 251
References 252
Chapter 7: The Folding Pathway of Triosephosphate Isomerase 260
I. Introduction 261
II. The Denaturation of TIM 263
III. The Reversibility of TIM Denaturation 263
IV. Models Describing TIM Denaturation 266
V. The Monomeric Intermediate 266
VI. The Folding Pathway of (beta/alpha)8 Proteins 268
VII. The Dimeric Intermediate 269
VIII. Energetic of the TIM Unfolding 270
IX. Final Remarks 271
References 272
Index 278
Color Plate Section 286

Produkt-Details

• Erscheint lt. Verlag: 9.1.2009
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• ISBN-10: 0-08-092339-9 / 0080923399
• ISBN-13: 978-0-08-092339-0 / 9780080923390