Advances in Molecular Toxicology (eBook)

eBook Download: PDF

2006 | 1. Auflage
200 Seiten
Elsevier Science (Verlag)
978-0-08-046538-8 (ISBN)

Infos

"Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.

* Cutting edge reviews by leading workers in the discipline.
* In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines.
* Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine."

Inhalt

Cover 1
Contents 6
Contributors 8
Editor’s Preface 10
Bioactivation of Estrogens to Toxic Quinones 14
Introduction 15
Mechanisms of Estrogen Carcinogenesis 15
Oxidation of Catechol Estrogens to O-Quinones 18
DNA Damage Induced by Catechol Estrogens 19
Protein Damage Induced by Catechol Estrogens 22
Role of the Estrogen Receptor in Estrogen Carcinogenesis 25
Substitution of the 4-Hydroxy group on Catechol Estrogens with Fluorine Abolishes Quinoid Formation while Maintaining Estrogenic Activity 27
Summary 28
Acknowledgment 29
References 29
Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA 38
Introduction 39
Simple Hydrolytic Mechanisms 43
Nitrosative Deamination and Inflammation 44
Enzymatic Deamination of Nucleobases 50
Purine Metabolism as a Source of Nucleobase Deamination in DNA and RNA 55
Repair and Mutagenesis of Nucleobase Deamination Products 59
Summary 62
Acknowledgments 63
References 63
Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression 78
Introduction 78
Patterns of Keap1 Modification by Electrophiles 80
Relationship of Keap1 Modification Sites and Functionally Significant Cysteine Residues 85
Electrophile-Induced Ubiquitination of Keap1 85
Unresolved Questions about Electrophile-Induced Activation of NRF2 90
Acknowledgments 92
References 92
Genotoxicity of Chlorophenols and Ochratoxin A 98
Introduction 98
Chlorophenols 101
Ochratoxin A 115
Acknowledgments 135
References 135
Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses 152
Background 152
Postulated Mechanisms 155
Summary and Conclusions 184
Acknowledgments 187
References 187
Subject Index 198

Produkt-Details

• Erscheint lt. Verlag: 13.10.2006
• Mitarbeit: Herausgeber (Serie): James C. Fishbein
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• ISBN-10: 0-08-046538-2 / 0080465382
• ISBN-13: 978-0-08-046538-8 / 9780080465388