Reflections on a Century of Malaria Biochemistry (eBook)

Irwin Sherman (Autor)

eBook Download: PDF

2011 | 1. Auflage
400 Seiten
Elsevier Science (Verlag)
978-0-08-092183-9 (ISBN)

Infos

Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa.
This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.
* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria
* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research

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Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa. This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases. - Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field- Chronicles both biochemical successes and failures

Inhalt

Front Cover 1
Advances in Parasitology 4
Copyright Page 5
Contents 6
Chapter 1: Introduction 9
Chapter 2: An Introduction to Malaria Parasites 11
Chapter 3: The Early Years 17
Chapter 4: Show Me the Money 23
Chapter 5: In Vivo and In Vitro Models 33
1. Life in the Erythrocyte 33
2. Life Outside the Erythrocyte 39
3. Life in the Mosquito 44
Chapter 6: Malaria Pigment 57
Chapter 7: Chloroquine and Hemozoin 67
Chapter 8: Isoenzymes 71
Chapter 9: The Road to the Plasmodium falciparum Genome 81
Chapter 10: Carbohydrate Metabolism 95
1. Glycolysis and the Tricarboxylic Acid Cycle 95
2. The Pentose Phosphate Pathway 97
3. Pyridine Nucleotides 99
4. Carbon Dioxide Fixation 100
Chapter 11: Pyrimidines and the Mitochondrion 103
Chapter 12: The Road to Atovaquone 109
Chapter 13: The Ring Road to the Apicoplast 113
Chapter 14: Ribosomes and Ribosomal Ribonucleic Acid Synthesis 119
Chapter 15: De Novo Synthesis of Pyrimidines and Folates 125
Chapter 16: Salvage of Purines 147
Chapter 17: Polyamines 155
Chapter 18: New Permeability Pathways and Transport 159
Chapter 19: Hemoglobinases 179
Chapter 20: Erythrocyte Surface Membrane Proteins 189
1. The Road to PfEMP1 189
2. PfEMP1, Knobs and Adhesion 198
3. PfEMP1 and Rosetting 202
4. PfEMP1 and Placental Adhesion 204
5. Knob-Associated Proteins Involved with Adhesion 205
6. Band 3 and Adhesion 207
7. Adhesion and Cerebral Malaria 210
Chapter 21: Trafficking 213
Chapter 22: Erythrocyte Membrane Lipids 223
Chapter 23: Invasion of Erythrocytes 237
Chapter 24: Vitamins and Anti-Oxidant Defenses 261
1. Vitamin B1 (Thiamin) 262
2. Vitamin B6 263
3. Pantothenate 265
4. Biotin (Vitamin B7) 265
5. Vitamin B3 (Niacin) 266
6. P-Aminobenzoic Acid 267
7. Riboflavin 268
8. Vitamins A, C, D and E 269
9. Anti-Oxidant Defenses 270
Chapter 25: Shocks and Clocks 279
Chapter 26: Transcriptomes, Proteomes and Data Mining 287
1. Transcriptomes 288
2. Proteomes 298
3. Data Mining 303
Chapter 27: Mosquito Interactions 307
1. Sexual Stages in the Blood 307
2. Gametogenesis and Ookinete Formation 309
3. Oocyst and Sporozoite Formation 319
4. Journey to the Liver 324
References 333
Index 403
Contents of Volumes in this Series 411

Produkt-Details

• Erscheint lt. Verlag: 29.8.2011
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Mathematik / Informatik ► Mathematik
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Technik
• ISBN-10: 0-08-092183-3 / 0080921833
• ISBN-13: 978-0-08-092183-9 / 9780080921839