Advances in Cancer Research (eBook)

George Klein, George F. Vande Woude (Herausgeber)

eBook Download: PDF

1997 | 1. Auflage
385 Seiten
Elsevier Science (Verlag)
978-0-08-056253-7 (ISBN)

Infos

Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok et all. Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

Inhalt

Cover 1
Contents 6
Contributors to Volume 71 10
Chapter 1. p53 and ATM: Cell Cycle, Cell Death, and Cancer 12
I. Introduction 12
II. The p53 Tumor Suppressor Gene 13
III. ATM 20
IV. Cell Cycle Control 27
References 30
Chapter 2. Deletions of the Short Arm of Chromosome 3 in Solid Tumors and the Search for Suppressor Genes 38
I. Tumor Suppressor Genes: The Concept 39
II. Methods of Localizing Tumor Suppressor Genes 41
III. Chromosome 3 Losses in Different Types of Tumors 46
IV. Functional Assays of Tumor Suppression on Chromosome 3 65
V. (Presumed) Tumor Suppressor Genes on the Short Arm of Chromosome 3 69
VI. Evolutionary Aspects of Human Chromosome 3 84
VII. Concluding Remarks 86
References 88
Chapter 3. Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer 104
I. Introduction 105
II. The HNPCC Syndrome 106
III. HNPCC and DNA MMR 108
IV. Mutations Predisposing to HNPCC 112
V. Phenotypic Effects of MMR Gene Mutations 122
VI. Implications of Mutation Findings 125
References 126
Chapter 4. Functional Aspects of Apoptosis in Hematopoiesis and Consequences of Failure 132
I. Introduction 133
II. Morphological and Biochemical Features of Apoptosis 134
III. Molecular Mechanisms in Apoptosis 136
IV. Functional Aspects of Apoptosis in the Hematopoietic System 142
V. Disruption of Apoptosis in Hematopoiesis 152
VI. Future Perspectives 163
References 165
Chapter 5. Cyclin-Dependent Kinase Regulation during G 1 Phase and Cell Cycle Regulation by TGF-ß 176
I. Introduction 177
II. Cyclins and Cyclin-Dependent Kinases 179
III. Conclusions 209
References 210
Chapter 6. The Natural Somatic Mutation Frequency and Human Carcinogenesis 220
I. Introduction 221
II. Somatic Mutation of Microsatellite Sequences 222
III. Somatic Mutations of Minisatellite Sequences 228
IV. Somatic Mutation of the HPRT Gene 228
V. The Frequency of Somatic Mutation in Solid Tissues Can Account for Multistep Carcinogenesis 232
VI. Cellular Proliferation as a Risk Factor for Cancer 233
VII. Germline Mutations 235
VIII. The Mutation Rate as the Fundamental Biological Pacemaker 242
IX. The Importance of Measuring Somatic Mutation Rates 244
X. The Mutational Clock and Cancer Prevention 245
References 246
Chapter 7. CD44: Structure, Function, and Association with the Malignant Process 252
I. Introduction 254
II. CD44 Nomenclature 256
III. CD44 Biochemical Structure 257
IV. CD44 Expression on Normal Cells 264
V. Hyaluronic Acid Is the Principal Ligand of CD44 270
VI. Non-HA Ligands of CD44 283
VII. Soluble CD44 285
VIII. Genetic Control of CD44 Expression 286
IX. CD44 Functions 286
X. Involvement of CD44 in Physiological and Pathological Cell Activities 296
XI. CD44 Association with the Malignant Process in Experimental Models 298
XII. CD44 Expression in Human Neoplasms and Its Correlation with the Malignant Status 302
XIII. CD44 Association with Malignancy: Some Practical Comments 315
XIV. Conclusions 316
References 318
Chapter 8. Human Papillomaviruses and Cervical Cancer 332
I. Introduction 332
II. Biology of Papillomaviruses 333
III. Taxonomy and Genomic Variability of Papillomaviruses 336
IV. Epidemiological Aspects 338
V. HPV Interaction with Cofactors 341
VI. Viral Persistence and Disease Progression 342
VII. Viral Burden and Cervical Disease 344
VIII. HPV in Cervical Screening Programs 344
References 346
Chapter 9. HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer 354
I. Introduction 355
II. HER-2/neu Vaccines For Cancer Therapy 357
III. Potential Pitfalls Associated with HER-2/neu-Specific Immunotherapy 367
IV. HER-2/neu-Specific Antibodies for Cancer Therapy 371
V. Conclusion 377
References 378
Index 384

Produkt-Details

• Erscheint lt. Verlag: 2.5.1997
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• ISBN-10: 0-08-056253-1 / 0080562531
• ISBN-13: 978-0-08-056253-7 / 9780080562537