Advances in Immunology (eBook)

Frank J. Dixon (Herausgeber)

eBook Download: PDF

1993 | 1. Auflage
342 Seiten
Elsevier Science (Verlag)
978-0-08-057829-3 (ISBN)

Infos

For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researchers and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.Advances in Immunology will keep you informed on such broadly defined subjects as: - Immunochemistry - Antibody synthesis - Biological action of antibodies - Immunological unresponsiveness - Mechanisms in innate and acquired immunity not involving antibodies - Specialized immunological techniques

Inhalt

Front Cover 1
Advances in Immunology, Volume 53 4
Copyright Page 5
Contents 6
Chapter 1. Lymphokine and Cytokine Production by FceRI+ Cells 10
I. Introduction 10
II. Biology of blast Cells and Basophils 10
III. Lymphokine Production by Transformed Murine Mast Cells 13
IV. Lymphokine Production by Factor-Dependent Miirine Mast Cell Lines 15
V. Lymphokine Production by Murine Peritoneal, Splenic, and Bone Marrow FceRI+ Cells 18
VI. Lymphokine Production by Human FceR+ Cells 23
VII. IL-4 Production by FceRI+ Cells in Infected or Iinmunized Mice 24
VIII. Does IL-4 Production by FceR+ Cells Play an Important Role in Determination of Lymphokine-Producing Phenotypes of CD4+ T Cells? 26
IX. Signaling Mechanisms Leading to IL-4 Production 28
X. Conclusion 31
References 32
Chapter 2. The Leukemia Inhibitory Factor and Its Receptor 40
I. Introduction 40
II. Purification and Molecular Cloning of the Leukemia Inhibitory Factor 40
III. The Leukemia Inhibitory Factor in Development 42
IV. Roles for LIF in Disease: Inflammation and Cachexia? 46
V. Molecular Characterization of the Leukemia Inhibitory Factor Receptor 47
VI. Life without LIF: The LIF Knockout Mouse 57
VII. Conclusions 58
References 59
Chapter 3. The Role of CD4 ond CD8 in T Cell Activation and Differentiation 68
I. Introduction 68
II. Function of CD4 and CD8 in T Cell Activation 68
III. Role of CD4 and CD8 i n T Cell Differentiation 103
References 123
Chapter 4. B Lymphopoiesis in the Mouse 132
I. Introduction 132
II. B Cells from Embryonic Stem Cells 133
III. Differential Expression of Lineage-Related Markers during B Cell Development in Different Body Sites 134
IV. Proliferation and Differentiation Capacities of B Cell Subpopulations 136
V. Possible Functions of the Surrogate L Chain in B Cell Differentiation 145
VI. Differentiation of Pre-B Cells to B Cells 149
VII. Genetic Defects Expressed in the B Lineage that Lead to Autoimmune Disease 153
References 156
Chapter 5. Compartmentalization of the Peripheral Immune System 166
I. Introduction 166
II. T Lymphocytes in Peripheral Compartments 168
III. B Cells in Peripheral Compartments 186
IV. Generation of Compartments 196
V. The Significance of Compartments 208
VI. Summary 213
References 214
Chapter 6. Immunological Memory 226
I. Introduction 226
II. Longevity and Maintenance of Immunological Memory 227
III. The T Cell Immune System and Immunological Memory 233
IV. The B Cell Immune System and Immunological Memory 239
V. The Life Span of T and B Cells and Relevance to Memory 247
VI. The Migration and Localization of Naive and Memory Cells 251
VII. Immunological Memory, Tolerance, and Autoimmunity 258
VIII. Concluding Remarks 262
References 263
Chapter 7. Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms 276
I. Introduction 276
II. Structure of Bacterial Lipopolysaccharide 277
III. Recognition of Lipid A by Receptor-Mediated Mechanisms 280
IV. Lipid A Structure-Function Relationships: Identification of Lipid A Antagonists 281
V. Identification of Membrane Proteins that Interact with Lipid 283
VI. The Role of the LBP/CD14 Pathway in LPS-Induced Macrophage Stimulation 290
VII. Summary 295
References 296
Chapter 8. Cell Adhesion Molecules as Targets of Autoantibodies in Pemphigus and Pemphigoid, Bullous Diseases Due to Defective Epidermal Cell Adhesion 300
I. Introduction 300
II. Clinical, Histologic, and Innmunopathologic Findings 300
III. Immunochemical Characterization of Pemphigoid and Pemphigus Antigens 306
IV. cDNA Cloning of Autoantigens 314
V. Conclusions and Future Directions 324
References 325
Index 336
Content of Recent Volumes 348

Produkt-Details

• Erscheint lt. Verlag: 17.6.1993
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• ISBN-10: 0-08-057829-2 / 0080578292
• ISBN-13: 978-0-08-057829-3 / 9780080578293