Annual Reports in Medicinal Chemistry (eBook)

eBook Download: PDF

1997 | 1. Auflage
378 Seiten
Elsevier Science (Verlag)
978-0-08-058376-1 (ISBN)

Infos

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.

Inhalt

Front Cover 1
Annual Report in Medicinal Chemistry, Volume 32 4
Copyright Page 5
CONTENTS 6
CONTRIBUTORS 10
PREFACE 12
SECTION I: CENTRAL NERVOUS SYSTEM DISEASES 14
Chapter 1. Recent Advances in Migraine Therapy 14
Chapter 2. Alzheimer’s Disease: Recent Advances on the Amyloid Hypothesis 24
Chapter 3. Obesity: Leptin - Neuropeptide Y Interactions in the Control of Body Weight 34
Chapter 4. Melatonin Receptor Ligands and Their Potential Clinical Applications 44
Chapter 5. Corticotropin-Releasing Hormone (CRH) Receptors and the Discovery of Selective Non-Peptide CRH, Antagonists 54
Chapter 6. Recent Advances in Neurokinin Receptor Antagonists 64
SECTION II: CARDIOVASCULAR AND PULMONARY DISEASES 74
Chapter 7. Endothelin Inhibitors 74
Chapter 8. Antithrombotics/Serins Proteases 84
Chapter 9. Leukotriene Modulators as Therapeutic Agents in Asthma and Other Inflammatory Diseases 104
Chapter 10. Emerging Opportunities in the Treatment of Atherosclerosis 114
SECTION III: CANCER AND INFECTIOUS DISEASES 124
Chapter 11. New Approaches and Agents to Overcome Bacterial Resistance 124
Chapter 12. Bacterial Genomics and the Search for Novel Antibiotics 134
Chapter 13. Resistance to Antiretroviral Drug Therapy 144
Chapter 14. Non-HIV Antiviral Agents 154
Chapter 15. Recent Advances in Antifungal Agents 164
Chapter 16. Angiogenesis Inhibitors 174
Chapter 17. Chemical Inhibitors of Cyclin-Dependent Kinases 184
SECTION IV: IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC DISEASES 194
Chapter 18. T Lymphocyte Potassium Channel Blockers 194
Chapter 19. Male Contraception 204
Chapter 20. New Dermatological Agents for the Treatment of Psoriasis 214
Chapter 21. Selective Cyclooxygenase-2 Inhibitors 224
Chapter 22. Growth Hormone Secretagogues 234
SECTION V: TOPICS IN BIOLOGY 8
Chapter 23. Novel Gene Switches for the Regulation of Gene Expression 244
Chapter 24. Agents that Block TNF-a Synthesis or Activity 254
Chapter 25. Nuclear Orphan Receptors: Scientific Progress and Therapeutic 264
SECTION VI: TOPICS IN DRUG DESIGN AND DISCOVERY 274
Chapter 26. Discovery and Identification of Lead Compounds from Combinatorial Mixtures 274
Chapter 27. Electrospray Mass Spectrometic Characterization of Adducts Between 269 Therapeutic Agents and Proteins 282
Chapter 28. Nonpeptide Agonists for Peptide Receptors: Lessons from Ligands 290
Chapter 29. Natural Products Research and Pharmaceuticals in the 1990’s 298
Chapter 30. Inhibition of Cytochrome P-450 and Implications in Drug Development 308
SECTION VII: TRENDS AND PERSPECTIVES 318
Chapter 31. To Market, To Market - 1996 318
COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX, VOLUME 32 340
CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOLUMES 1-32 348
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1996 362
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1996, (BY INDICATION) 376

Produkt-Details

• Erscheint lt. Verlag: 8.10.1997
• Mitarbeit: Herausgeber (Serie): Annette M. Doherty, William K. Hagmann, Jacob J. Plattner, David Robertson, George L. Trainor, Winnie W. Wong; Chef-Herausgeber: James A. Bristol
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• ISBN-10: 0-08-058376-8 / 0080583768
• ISBN-13: 978-0-08-058376-1 / 9780080583761