Comprehensive Sourcebook of Bacterial Protein Toxins (eBook)

Joseph E. Alouf, Daniel Ladant, Michel R. Popoff (Autoren)

eBook Download: PDF

2005 | 3. Auflage
1072 Seiten
Elsevier Science (Verlag)
978-0-08-045698-0 (ISBN)

Infos

Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.

* Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France
* 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology
* Includes the major toxins of both basic and clinical interest are described in depth
* Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology
* Evolutionary and functional aspects of bacterial toxins evaluated and summarized
* Toxin applications in cell biology presented
* Therapy (cancer therapy, dystonias) discussed
* Vaccines (native and genetically engineered vaccines) featured
* Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Inhalt

front cover 1
coypright 5
In Memoriam 6
table of contents 8
front matter 12
Contributors 12
Preface to Third Edition 18
Preface to Second Edition 20
Preface to First Edition 22
Introduction 24
body 26
INTRODUCTORY SECTION 26
1 A 116-year story of bacterial protein toxins (1888-2004): from "diphtheritic poison" to molecular toxinology 28
SECTION I BASIC GENOMIC AND PHYSIOLOGICAL ASPECTS OF BACTERIAL PROTEIN TOXINS 48
2 Evolutionary aspects of toxin-producing bacteria 50
3 Mobile genetic elements and pathogenicity islands encoding bacterial toxins 69
4 Regulation systems of toxin expression 89
5 Toxin secretion systems 108
6 Toxin receptors 131
7 Translocation of bacterial protein toxins into the cytosol 145
8 Intracellular trafficking of bacterial and plant protein toxins 160
9 Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular junctions 179
10 Bacterial toxins and mitochondria 213
11 Toxins activating Rho GTPases and exploiting the cellular ubiquitin/ proteasome machineries 227
SECTION II BACTERIAL PROTEIN TOXINS ACTING IN THE INTRACELLULAR COMPARTMENT OF EUKARYOTIC CELLS 236
12 Molecular, functional, and evolutionary aspects of ADP-ribosylating toxins 238
13 Diphtheria toxin 270
14 Pseudomonas aeruginosa toxins 282
15 Vibrio cholerae and Escherichia coli thermolabile enterotoxin 295
16 Bordetella protein toxins 316
17 The Shiga toxins: properties and action on cells 335
18 Bacillus anthracis toxins 348
19 Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular actions 373
20 Uptake and transport of clostridium neurotoxins 415
21 Large clostridial cytotoxins modifying small GTPases 434
22 Pasteurella multocida toxin 455
23 Cytolethal distending toxins 473
24 Helicobacter pylori vacuolating toxin 493
25 Escherichia coli heat-stable enterotoxin b 516
SECTION III TOXINS ACTING ON THE SURFACE OF TARGET CELLS (EXCEPT SUPERANTIGENS) 530
26 Paradigms and classification of bacterial membrane-damaging toxins 532
27 Membrane-damaging and cytotoxic phospholipases 541
28 Bacteroides fragilis toxins 560
29 Structure and mode of action of RTX toxins 572
30 Genetics and phylogeny of RTX cytolysins 595
31 The family of two-component cytolysins of Serratia and other bacteria 603
32 Alpha-helix and beta-barrel pore-forming toxins (leucocidins, alpha-, gamma-, and delta-cytolysins) of Staphylococcus aureus 615
33 Aerolysin and related Aeromonas toxins 633
34 Clostridium septicum pore-forming a-toxin 648
35 Clostridium perfringens e-toxin 656
36 Repertoire and general features of the family of cholesterol- dependent cytolysins 668
37 Comparative three-dimensional structure of cholesterol-dependent cytolysins 684
38 Perfringolysin O and intermedilysin: mechanisms of pore formation by the cholesterol-dependent cytolysins 696
39 Pneumolysin: structure, function, and role in disease 705
40 Listeriolysin 725
41 Enterococcus faecalis cytolysin toxin 742
42 Streptolysin S: one of the most potent and elusive of all bacterial toxins 753
43 The group B streptococcal ß-hemolysin/cytolysin 762
44 Hemolysins of vibrio cholerae and other vibrio species 773
45 Clostridium perfringens enterotoxin 788
46 Bacillus cereus enterotoxins, bi- and tri-component cytolysins, and other hemolysins 804
47 Uropathogenic Escherichia coli cytolysins 816
48 Escherichia coli, Vibrio, and Yersinia species heat-stable enterotoxins 823
SECTION IV SUPERANTIGENIC TOXINS 844
49 What are superantigens? 846
50 Staphylococcal superantigens and the diseases they cause 855
51 Streptococcal superantigenic toxins 869
52 The superantigenic toxin of Yersinia pseudotuberculosis 887
53 Comparative three-dimensional structure of bacterial superantigenic toxins 897
SECTION V CLINICAL, IMMUNOLOGICAL ASPECTS AND APPLICATIONS OF BACTERIAL PROTEIN TOXINS IN CELL BIOLOGY AND THERAPY 910
54 Induction and modulation of inflammatory networks by bacterial protein toxins 912
55 Clostridial toxins in the pathogenesis of gas gangrene 944
56 Staphylococcal exfoliative toxins 955
57 Bacterial toxins as food poisons 974
58 Medical applications of botulinum neurotoxins 984
59 Toxins as tools 1001
60 Engineering of bacterial toxins for research and medicine 1016
61 Engineered bacterial toxin vaccines and adjuvants 1033
62 Bacterial protein toxins as biological weapons 1044
index 1056

Produkt-Details

• Erscheint lt. Verlag: 20.12.2005
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• ISBN-10: 0-08-045698-7 / 0080456987
• ISBN-13: 978-0-08-045698-0 / 9780080456980