Neurobiology of C. elegans (eBook)

Eric James Aamodt (Herausgeber)

eBook Download: PDF

2006 | 1. Auflage
248 Seiten
Elsevier Science (Verlag)
978-0-08-047861-6 (ISBN)

Infos

The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.

Inhalt

Cover 1
Title 2
Series Editors 3
Copyright 5
Contents 6
Contributors 10
Preface 12
Chapter 1: Nematode Neurons: Anatomy and Anatomical Methods in Caenorhabditis elegans 15
I. Introduction 16
II. Categorization of Neuron Cell Fates 19
III. What Defines a Neuron? Synapses, Scaffolds, and Pioneers 28
IV. Neuron Ultrastructure 31
V. Methods for Analytical Study of Neurons in C. elegans 38
References 44
Chapter 2: Investigations of Learning and Memory in Caenorhabditis elegans 51
I. Introduction 52
II. Mechanosensory Learning and Memory 54
III. Chemosensory Learning and Memory 66
IV. Thermosensory Learning and Memory 75
V. Conclusions 81
References 82
Chapter 3: Neural Specification and Differentiation 87
I. Introduction 88
II. HOM-C Genes 93
III. Basic Helix-Loop-Helix Genes 95
IV. Neurogenesis of the Touch Receptor Neurons 100
V. The LIM Hypothesis 105
VI. Mutations That Cause the Partial Loss of Neuronal Identity 106
VII. Conclusions 107
References 107
Chapter 4: Sexual Behavior of the Caenorhabditis elegans Male 113
I. In C. elegans, Sex is the Male's Responsibility 114
II. Mate-Searching Demonstrates Motivated Behavior in the Worm 115
III. Hermaphrodite Cues Influence Male Locomotory Behavior 115
IV. Male Copulatory Behavior can be Broken Down into a Series of Sub-Behaviors 117
V. The Gender-Specific Anatomy and Nervous System of the Male Develop Postembryonically 120
VI. The Fan Facilitates the Male's Contact with the Hermaphrodite Body 120
VII. Each Sub-Behavior of the Copulatory Sequence is Promoted by Sensory Input from Particular Sensory Neurons 122
VIII. The Rays Convey Complex Spatial Information 123
IX. Hook, Post-Cloacal Sensilla, and Spicules Detect the Vulva 126
X. Spicule Insertion Anchors the Male and Triggers Ejaculation 127
XI. The Male's Copulatory Nervous System can Take Over Control of the Rest of the Nervous System 128
XII. Male Development Results from Gender-Specific Utilization of a Largely Common Set of Genes 129
XIII. DM Domain Transcription Factors may Represent Primordial Male-Determining Genes 129
XIV. Response to Contact and Vulva Location Require Genes of the TRP Channel Superfamily of Putative Mechanosensitive Channels 131
XV. Multiple Cholinergic Pathways Regulate the Muscle Contractions Controlling Spicule Behavior 131
XVI. Prospects 134
References 135
Chapter 5: The Motor Circuit 139
I. Introduction 140
II. An Overview of C. elegans Motor Circuit Anatomy 140
III. Genetic Control of Motor Neuron Differentiation 154
IV. How Does It Work? 167
V. Conclusions and Future Directions 172
References 174
Chapter 6: Mechanosensation in Caenorhabditis elegans 183
I. Introduction 184
II. Gentle Touch 187
III. Harsh Touch 200
IV. Osmolarity 201
V. Nose Touch 201
VI. Texture-Mediated Slowing 205
VII. Proprioception and Sinusoidal Locomotion 206
VIII. Male Mating and Location of the Vulva 207
IX. Conclusions and Future Directions 210
References 210
Index 219
Contents of Recent Volumes 227

Produkt-Details

• Erscheint lt. Verlag: 2.2.2006
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Geisteswissenschaften ► Psychologie ► Allgemeine Psychologie
• Themenwelt: Geisteswissenschaften ► Psychologie ► Biopsychologie / Neurowissenschaften
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• ISBN-10: 0-08-047861-1 / 0080478611
• ISBN-13: 978-0-08-047861-6 / 9780080478616