Regulators of G Protein Signaling, Part B (eBook)

David Siderovski (Herausgeber)

eBook Download: PDF

2004 | 1. Auflage
560 Seiten
Elsevier Science (Verlag)
978-0-08-049727-3 (ISBN)

Infos

This volume continues the in-depth treatment of the topic and covers the RSG protein superfamily including RZ, R4, R7, R12, RhoGEF, and GRK, as well as other heterotrimeric G-protein signaling regulators.

Table of Contents
-RZ Subfamily
-R4 Subfamily
-R7 Subfamily
-R12 Subfamily
-RhoGEF Subfamily
-GRK Subfamily
-Other RGS proteins
-Activators
-Inhibitors
-Other Modulators

---

Regulators of G Protein Signaling, Part B continues the in-depth treatment of the topic and covers the RSG protein superfamily including RZ, R4, R7, R12, RhoGEF, and GRK, as well as other heterotrimeric G-protein signaling regulators. - Table of Contents- RZ Subfamily- R4 Subfamily- R7 Subfamily- R12 Subfamily- RhoGEF Subfamily- GRK Subfamily- Other RGS proteins- Activators- Inhibitors- Other Modulators

Inhalt

Cover 1
Table of Contents 6
Contributors to Volume 390 10
Preface 14
Volumes in Series 18
Section I: The RGS Protein Superfamily 40
Subsection A: RZ Subfamily 42
Chapter 1. Evaluating Chick Ga-Interacting Protein Selectivity 42
Chapter 2. Analyses of Ga-Interacting Protein and Activator of G-Protein-Signaling-3 Functions in Macroautophagy 56
Chapter 3. Analysis of RGSZ1 Protein Interaction with Gai Subunits 70
Chapter 4. Analysis of the Regulation of Microtubule Dynamics by Interaction of RGSZ1 (RGS20) with the Neuronal Stathmin, SCG10 92
Subsection B: R4 Subfamily 104
Chapter 5. RGS2-Mediated Regulation of Gqa 104
Chapter 6. Analysis of the Interaction between RGS2 and Adenylyl Cyclase 122
Chapter 7. Assays of RGS3 Activation and Modulation 138
Chapter 8. Analysis of PDZ-RGS3 Function in Ephrin-B Reverse Signaling 159
Chapter 9. Biochemical and Electrophysiological Analyses of RGS8 Function 168
Subsection C: R7 Subfamily 188
Chapter 10. Biochemical Purification and Functional Analysis of Complexes between the G-Protein Subunit GB5 and RGS Proteins 188
Chapter 11. Purification and In Vitro Functional Analysis of R7 Subfamily RGS Proteins in Complex with GB5 202
Chapter 12. Characterization of R9AP, a Membrane Anchor for the Photoreceptor GTPase- Accelerating Protein, RGS9-1 217
Chapter 13. Kinetic Approaches to Study the Function of RGS9 Isoforms 235
Chapter 14. Assays of Nuclear Localization of R7/GB5 Complexes 249
Subsection D: R12 Subfamily 263
Chapter 15. Mapping of RGS12-Cav2.2 Channel Interaction 263
Chapter 16. Analysis of Interactions between Regulator of G-Protein Signaling-14 and Microtubules 279
Subsection E: RhoGEF Subfamily 298
Chapter 17. Modular Architecture and Novel Protein–Protein Interactions Regulating the RGS-Containing Rho Guanine Nucleotide Exchange Factors 298
Chapter 18. Regulation of RGS-RhoGEFs by Ga12 and Ga13 Proteins 324
Subsection F: GRK Subfamily 334
Chapter 19. Analysis of G-Protein-Coupled Receptor Kinase RGS Homology Domains 334
Chapter 20. Characterization of GRK2 RH Domain-Dependent Regulation of GPCR Coupling to Heterotrimeric G Proteins 349
Chapter 21. Analysis of Differential Modulatory Activities of GRK2 and GRK4 on Gaq-Coupled Receptor Signaling 376
Subsection G: Other RGS Proteins 393
Chapter 22. Identification and Functional Analysis of Dual- Specific A Kinase-Anchoring Protein-2 393
Section II: Other Heterotrimeric G-Protein Signaling Regulators 414
Subsection A: Activators 416
Chapter 23. Purification and Functional Analysis of Ric- 8A: A Guanine Nucleotide Exchange Factor for G-Protein a Subunits 416
Chapter 24.Tubulin as a Regulator of G-Protein Signaling 428
Chapter 25. Nucleoside Diphosphate Kinase–Mediated Activation of Heterotrimeric G Proteins 442
Subsection B: Inhibitors 458
Chapter 26. Purification and In Vitro Functional Analyses of RGS12 and RGS14 GoLoco Motif Peptides 458
Chapter 27. GoLoco Motif Peptides as Probes of G a Subunit Specificity in Coupling of G-Protein-Coupled Receptors to Ion Channels 476
Subsection C: Other Modulators 490
Chapter 28. Experimental Systems for Studying the Role of G-Protein-Coupled Receptors in Receptor Tyrosine Kinase Signal Transduction 490
Chapter 29. Identification and Biochemical Analysis of GRIN1 and GRIN2 514
Author Index 524
Subject Index 544

Produkt-Details

• Erscheint lt. Verlag: 16.11.2004
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-08-049727-6 / 0080497276
• ISBN-13: 978-0-08-049727-3 / 9780080497273