Advances in Drug Research (eBook)

Urs A. Meyer, Bernard Testa (Herausgeber)

eBook Download: PDF

1996 | 1. Auflage
374 Seiten
Elsevier Science (Verlag)
978-0-08-052671-3 (ISBN)

Infos

This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

Inhalt

Cover 1
Contents 4
Contributors 8
Preface: Circles in drug research 9
Chapter 1. Stereochemical Aspects of Drug Action and Disposition 12
1 Introduction 13
2 Stereoselectivity in Drug Action 14
3 Stereoselectivity in Drug Disposition 25
4 Stereoselectivity and Toxicity 53
5 Implications and Consequences 54
6 Drug Development 62
7 Conclusion 65
References 66
Chapter 2. Advances in the Development of Pharmaceutical Antioxidants 76
1 Introduction 78
2 Endogenous Defence Systems 89
3 Semisynthetic Analogues of Endogenous Antioxidants 96
4 Natural Products 103
5 Synthetic Antioxidants 121
6 Clinical Agents 151
7 Conclusions 174
Acknowledgements 176
References 176
Chapter 3. Multidrug Resistance of Cancer Cells 192
1 Introduction and Overview 193
2 MDR1 and Clinical Multidrug Resistance 196
3 Mechanism of Action of the MDR1 Gene Product 208
4 MDR1 Gene Regulation 230
5 Other Mechanisms of Multidrug Resistance 237
6 Prospects for Pgp-related Chemotherapy 243
Acknowledgements 248
References 249
Chapter 4. Bioactivation of Organic Nitrates and Other Nitrovasodilators 264
1 Introduction 264
2 Nitric Oxide and Cyclic GMP as Meditiaiors of Organic Nitrate Action 265
3 Nitric Oxide Formation from Organic Nitrates in Cell-free Systems 265
4 Cytochrome P450 as a Mediator of Nitric Oxide Formation from Organic Nitrates in Intact Cells 268
5 Unanswered Questions 271
6 Outlook 274
References 275
Chapter 5. The Vitamin D Endocrine System and its Therapeutic Potential 280
1 Historical Introduction 281
2 Biosynthesis of Vitamin D 283
3 Metabolism of Vitamin D 284
4 Mechanism of Action of 1,25-(OH)2D3 291
5 Functions of Vitamin D 297
6 Regulation of the Vitamin D Endocrine System 303
7 Therapeutic Uses of Vitamin D Metabolites and Analogues 305
8 Conclusions and Future Directions 312
Acknowledgements 313
References 313
Chapter 6. Dopamine Receptors : Studies on Structure and Function 324
1 Multiple Dopamine Receptors 326
2 Common Properties of Dopamine Receptor Subtypes Defined by Molecular Biology 326
3 Distinct Properties of the Dopamine Receptor Subtypes Defined by Molecular Biological Techniques 331
4 The Mechanism of Binding of Ligands to Dopamine Receptors 337
5 Conclusions 357
References 358
Subject Index 364
Cumulative Index of Authors 378
Cumulative Index of Titles 382

Produkt-Details

• Erscheint lt. Verlag: 2.7.1996
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 0-08-052671-3 / 0080526713
• ISBN-13: 978-0-08-052671-3 / 9780080526713