Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology (eBook)

Urs A. Meyer, Bernard Testa (Herausgeber)

eBook Download: PDF

1996 | 1. Auflage
231 Seiten
Elsevier Science (Verlag)
978-0-08-052670-6 (ISBN)

Infos

Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.

Inhalt

Cover 1
Copyright Page 5
Contents 6
Contributors 10
Foreword 12
Preface 14
Abbreviations 16
Introduction 20
Chapter 1. Regulation of Glucose Homoeostasis 22
1 Introduction 22
2 Effect of Insulin Deficiency 26
3 Regulation of Glucose Homoeostatis in Type-I Diabetes Mellitus (IDDM) 28
4 Regulation of Glucose Homoeostasis in Type-II Diabetes Mellitus (NIDDM) 32
Chapter 2. Clinical Aspects of Diabetes Mellitus 36
1 Type-I Diabetes Mellitus 36
2 Type-II Diabetes Mellitus 40
Chapter 3. Mechanisms of Insulin Action 44
1 Insulin Actions 44
2 Insulin Receptor 45
3 Signal Transduction 51
4 Effector Systems of Insulin Signals: A Limited Selection 61
Chapter 4. Therapeutic Use of Insulin 68
1 Chemistry 69
2 Preparations 69
3 Application of Insulins 71
4 Pharmacokinetics 72
5 Toxic Effects 74
6 Side Effects 74
7 Clinical Studies of Insulin-replacement Therapy 88
Chapter 5. The Secretory Machinery of Insulin Release 96
1 Introduction 96
2 Route by which Initiators and Modulators Reach the B-Cell 97
3 Initiation of Insulin Secretion 98
4 Modulation of Insulin Secretion via Adenylate Cyclase and Phospholipase C (PLC) 111
5 Concept of Initiation and Modulation of Insulin Secretion 125
Chapter 6. Compounds Acting on Insulin Secretion: Sulphonylureas 126
1 Chemical Structure 127
2 Actions 127
3 Pharmacokinetics 136
4 Toxic Effects 140
5 Side Effects 141
6 Interaction with Other Drugs 146
7 Clinical Studies 148
Chapter 7. Compounds Acting on Glucose Absorption 170
1 Guar 170
2 Acarbose 178
Chapter 8. Aldose Reductase Inhibitors as New Antidiabetic Drugs 190
1 Chemistry 190
2 Functions of Aldose Reductase 191
3 Action of Aldose Reductase Inhibitors 192
4 Pharmacokinetics 194
5 Pathological Changes in the Pharmacokinetics 195
6 Toxic and Side Effects 195
7 Interaction with Other Drugs 196
8 Clinical Trials 196
Conclusions 198
References 200
Subject Index 234
Cumulative Index of Authors 248
Cumulative Index of Titles 252

Produkt-Details

• Erscheint lt. Verlag: 8.5.1996
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 0-08-052670-5 / 0080526705
• ISBN-13: 978-0-08-052670-6 / 9780080526706