Biological Weapons Defense (eBook)

Infectious Disease and Counterbioterrorism

Luther E. Lindler, Frank J. Lebeda, George Korch (Herausgeber)

eBook Download: PDF

2007 | 2005
XXII, 598 Seiten
Humana Press (Verlag)
978-1-59259-764-2 (ISBN)

Infos

In 2003, the President's budget for bioterrorism defense totalled more than $5 billion. Today, the nation's top academic scientists are scrambling to begin work to understand Bacillus anthracis and develop new vaccines and drugs. However, just five years ago, only the US Department of Defense (DOD) seemed concerned about these 'exotic' agents. In 1997, the DOD spent approximately $137 million on biodefense to protect the deployed force, while academe, industry, local governments, and most of our federal leadership was oblivious to, and in some cases doubtful of, the seriousness of the threat. The National Institutes of Health (NIH) received the largest budget increase in the organization's history. Fortunately, during this time of national urgency, a sound base exists on which to build our defenses against this new threat. A relatively small cadre of dedicated scientists within the US Army Medical Research and Materiel Command (USAMRMC) laid this foundation over the past 20 years.

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In 2003, the President's budget for bioterrorism defense totalled more than $5 billion. Today, the nation's top academic scientists are scrambling to begin work to understand Bacillus anthracis and develop new vaccines and drugs. However, just five years ago, only the US Department of Defense (DOD) seemed concerned about these "e;exotic"e; agents. In 1997, the DOD spent approximately $137 million on biodefense to protect the deployed force, while academe, industry, local governments, and most of our federal leadership was oblivious to, and in some cases doubtful of, the seriousness of the threat. The National Institutes of Health (NIH) received the largest budget increase in the organization's history. Fortunately, during this time of national urgency, a sound base exists on which to build our defenses against this new threat. A relatively small cadre of dedicated scientists within the US Army Medical Research and Materiel Command (USAMRMC) laid this foundation over the past 20 years.

Inhalt

I. Preparation and Military Support for a Possible Bioterrorism Incident

Department of Defense Capabilities Supporting Bioterrorism Response
Anna Johnson-Winegar, Karl Semancik, Robert S. Borowski, Keith R. Vesely, Brenda Wyler, Matt Eussen, and John V. Wade

Modeling for Bioterrorism Incidents
Zygmunt F. Dembek

Biological Weapons Defense: Effect Levels
Ross D. LeClaire and M. Louise M. Pitt

II. Medical Countermeasures and Decontamination

Pathogenesis by Aerosol
M. Louise M. Pitt and Ross D. LeClaire

Bacillus anthracis and the Pathogenesis of Anthrax
Dominique M. Missiakas and Olaf Schneewind

Virologic and Pathogenic Aspects of the Variola Virus (Smallpox) as a Bioweapon
Robert G. Darling, Timothy H. Burgess, James V. Lawler, and Timothy P. Endy

Plague Vaccines: Retrospective Analysis and Future Developments
Jeffrey J. Adamovicz and Gerard P. Andrews

Medical Protection Against Brucellosis
David L. Hoover and Richard H. Borschel

Pathogenesis of and Immunity to Coxiella burnetii
David M. Waag and Herbert A. Thompson

Glanders: New Insights Into an Old Disease
David M. Waag and David DeShazer

Medical Countermeasures for Filoviruses and Other Viral Agents
Alan Schmaljohn and Michael Hevey

Medical Defense Against Protein Toxin Weapons: Review and Perspective
Charles B. Millard

Antimicrobials for Biological Warfare Agents
Jon B. Woods

Nonspecific Immunomodulator Therapy: CpG
D. G. Cerys Rees, Arthur M. Krieg, and Richard W. Titball

Decontamination
Robert J. Hawley and Joseph P. Kozlovac

III. Emerging Threats and Future Preparation

Definition and Overview of Emerging Threats
Luther E. Lindler, Eileen Choffnes, and George W. Korch

Department of Defense Global Emerging Infections System Programs in Biodefense
Julie A. Pavlin and Patrick W. Kelley

Information Resources and Database Development for Defense Against Biological Weapons
Frank J. Lebeda, Murray Wolinsky, and Elliot J. Lefkowitz

Genomic Efforts With Biodefense Pathogens
Rekha Seshadri, Timothy D. Read, William C. Nierman, and Ian T. Paulsen

Genomics for Biodefense: Exploiting the Francisella tularensis Genome Sequence
Siv G. E. Andersson, Mats Forsman, Petra C. F. Oyston, and Richard W. Titball

Genetic Fingerprinting of Biodefense Pathogens for Epidemiology and Forensic Investigation
Luther E. Lindler, Xiao-Zhe Huang, May Chu, Ted L. Hadfield, and Michael Dobson

Yersinia pestis as an Emerged Pathogen: What Lessons Can Be Learned?
Luther E. Lindler

IV. Diagnostic Development for Biowarfare Agents

Requirements for Biological Threat Identification Systems
Erik A. Henchal and George V. Ludwig

DNA-Based Diagnostic Tests for Detection and Identification of Biological Weapons
Luther E. Lindler, David Norwood, Michael Dobson, and Ted L. Hadfield

Concepts for the Development of Immunodiagnostic Assays for Detection and Diagnosis of Biothreat Agents
George V. Ludwig, Cynthia A. Rossi, and Robert L. Bull

Index

Produkt-Details

• Erscheint lt. Verlag: 27.10.2007
• Reihe/Serie: Infectious Disease
• Reihe/Serie: Infectious Disease
• Zusatzinfo: XXII, 598 p. 78 illus.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Natur / Technik ► Fahrzeuge / Flugzeuge / Schiffe ► Militärfahrzeuge / -flugzeuge / -schiffe
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Sozialwissenschaften ► Politik / Verwaltung ► Politische Theorie
• Themenwelt: Technik
• Schlagworte: Antimicrobial • biological weapons • Infection • Infections • Infectious • infectious disease • Infectious Diseases • Virus
• ISBN-10: 1-59259-764-5 / 1592597645
• ISBN-13: 978-1-59259-764-2 / 9781592597642