Host Defense Dysfunction in Trauma, Shock and Sepsis
Springer Berlin (Hersteller)
978-3-540-55329-8 (ISBN)
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Severe injury to the human body may cause its immunological defence mechanisms to be so altered that they can no longer prevent multiple organ failure. This study describes the sequence of events leading from injury to impaired defence response to multiple organ dysfunction syndrome.
When the human body is injured, its immunological defence mechanisms may be so injured or altered that they can no longer prevent multiple organ failure. The sequence of events leading from injury to impaired defence response to multiple organ dysfunction syndrome are reviewed here. First, basic mechanisms are discussed - the crucial alterations of immune and inflammatory mechanisms, the role of endotoxin and potential counterregulatory strategies to neutralize endotoxin in order to prevent shock, major etiological factors leading to organ failure, and cytokines and the modulation of cytokine action. In the discussion of the clinical aspects of multiple organ failure, the antibiotic interactions with host defenses, the augmentation of immunoreactivity with special nutrients and the newest insights into the regulation of wound repair are elucidated. The final sections of the book deal with therapeutic immunomodulatory approaches for the prevention of infections and with interventional strategies in the therapy of septic shock.
Contents: General Aspects/Perspectives.- Host defense integrity, response and stress.- From injury to multiple organ failure: Sequential steps of host defense impairment.- Immune mechanisms for the control of infection under physiologic and stressful conditions.- Inflammatory mechanisms in traumatic and septic injury.- Hepatocellular injury in ischemia, trauma and sepsis.- Cytokines and modulation of cytokine action.- Cytokines in acute phase states and trauma.- The mediator role of TNF in sepsis.- Endotoxin - mechanisms of actions and protection from shock.- Clinical aspects of multiple organ failure.- The pathophysiologic impact of bacterial translocation and strategies for its prevention.- Antibiotic interactions with host defenses.- The role of nutrition in host defense.- New insight into the mechanisms of wound healing.- Therapeutic immunomodulatory approaches: Prevention.- Endotoxin neutralization with IV-immunogloblins and monclonal anti-endotoxin antibodies.-
| Zusatzinfo | 416 figs., 153 tabs. |
|---|---|
| Sprache | englisch |
| Gewicht | 2170 g |
| Einbandart | gebunden |
| Schlagworte | Immunschwäche • Organversagen • Schock (med.) • Schock (Medizin) • Sepsis • Sepsis / Blutvergiftung • Trauma (Medizin) |
| ISBN-10 | 3-540-55329-0 / 3540553290 |
| ISBN-13 | 978-3-540-55329-8 / 9783540553298 |
| Zustand | Neuware |
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