Biomolecular Thermodynamics
Crc Press Inc (Verlag)
978-1-4398-0019-5 (ISBN)
"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus…. the ample problems and tutorials throughout are much appreciated."
–Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago
"Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels."
–Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University
"a masterful tour de force…. Barrick's rigor and scholarship come through in every chapter."
–Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis
This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation.
Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned a Ph.D. in biochemistry from Stanford University (1993) and Ph.D. in biophysics and structural biology from the University of Oregon (1996). He has been honored as recipient of the Beckman Young Investigator award, the Helen Hay Whitney Postdoctoral fellowship, and Howard Hughes Medical Institute Predoctoral Fellowship. He has been an editorial board member of the journals Protein Science and Biophysical Journal, and has been an organizer of the Gibbs Conference on Biothermodynamics. Research in his lab focuses on the study of protein evolution, folding, and assembly.
Series Preface
Preface
Acknowledgments
Note to Instructors
Author
Chapter 1 Probabilities and Statistics in Chemical and Biothermodynamics
Chapter 2 Mathematical Tools in Thermodynamics
Chapter 3 The Framework of Thermodynamics and the First Law
Chapter 4 The Second Law and Entropy
Chapter 5 Free Energy as a Potential for the Laboratory and for Biology
Chapter 6 Using Chemical Potentials to Describe Phase Transitions
Chapter 7 The Concentration Dependence of Chemical Potential, Mixing, and Reactions
Chapter 8 Conformational Equilibrium
Chapter 9 Statistical Thermodynamics and the Ensemble Method
Chapter 10 Ensembles That Interact with Their Surroundings
Chapter 11 Partition Functions for Single Molecules and Chemical Reactions
Chapter 12 The Helix–Coil Transition
Chapter 13 Ligand Binding Equilibria from a Macroscopic Perspective
Chapter 14 Ligand Binding Equilibria from a Microscopic Perspective
Appendix: How to Use Mathematica 485
Bibliography
Index
| Erscheint lt. Verlag | 19.10.2017 |
|---|---|
| Reihe/Serie | Foundations of Biochemistry and Biophysics |
| Zusatzinfo | 40 Tables, black and white; 248 Line drawings, black and white; 7 Halftones, black and white; 255 Illustrations, black and white |
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 210 x 280 mm |
| Gewicht | 1512 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik | |
| Naturwissenschaften ► Physik / Astronomie ► Thermodynamik | |
| ISBN-10 | 1-4398-0019-7 / 1439800197 |
| ISBN-13 | 978-1-4398-0019-5 / 9781439800195 |
| Zustand | Neuware |
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