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Thrombin

Physiology and Disease

Michael E. Maragoudakis, Nikos E. Tsopanoglou (Herausgeber)

Buch | Hardcover

266 Seiten

2008 | 2009 ed.
Springer-Verlag New York Inc.
978-0-387-09636-0 (ISBN)

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In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields.

This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Thrombin: Structure, Functions, and Regulation.- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation.- Regulation of Thrombin Receptor Signaling.- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology.- The Role of Thrombin in Vascular Development.- The Role of Thrombin in Angiogenesis.- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair.- The Role of Thrombin and Thrombin Receptors in the Brain.- The Role of Thrombin in Tumor Biology.- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation.- Anti-thrombotic Therapy in Cancer Patients.- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application.- Novel Anticoagulant Therapy: Principle and Practice.

Erscheint lt. Verlag	2.12.2008
Zusatzinfo	XII, 266 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	0-387-09636-1 / 0387096361
ISBN-13	978-0-387-09636-0 / 9780387096360
Zustand	Neuware