Oxidative Stress and Aging

From Chemistry to Human Dietary Supplements

Toshinori Hoshi, Robert J. Pignolo, Stefan Heinemann (Herausgeber)

Buch | Hardcover

400 Seiten

2009 | 2012
Humana Press Inc. (Verlag)
978-1-60327-548-4 (ISBN)

Infos

This book on oxidative stress and aging roughly follows the complexity hierarchy from molecules to organisms with each section covering pro- and anti-oxidant components and human implications. The final chapter focuses on lifespan extension strategies.

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Oxidative stress and aging is a multi-dimensional/factorial subject matter encompassing different degrees of organism complexity (from single-cell animals to humans), different molecules (DNA, RNAs, proteins and lipids), different cellular components (mitochondria, cytoplasm and plasma membrane), different tissues and organs, and different human subpopulations including those with different 'lifestyles'. This book roughly follows this complexity hierarchy, from molecules to organisms; and within each section, pro- and anti-oxidant components will be presented and human implications will be discussed. Some overlap in coverage of topics is anticipated and this is deemed both necessary and preferable for the existing literature is often controversial. The book concludes with a chapter focusing on possible lifespan extension strategies based on our understanding of oxidative stress protection. A short preface in each of the major sections will be included to summarize the section and briefly mention other topics not specifically covered by the chapters within. The following chapter titles are tentative and will be adjusted according the contributors' preferences.

Inhalt

Section I Introduction Oxidation, Aging and lifespan: an overview and a brief assessment of the oxidative damage theory of aging. Arlan Richardson, Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 [e-mail] Experimental measurements and statistical analysis of aging and lifespan David Allison, University of Alabama Birmingham, Birmingham, AL. [e-mail] Oxidative chemistry and markers of damaged molecules Harry Ischiropoulos, University of Pennsylvania, Philadelphia, PA Section II Oxidative Stress Targets and Aging DNA damage Ryszard Olinksy, Department of Clinical Biochemistry, Nicolaus Copernicus University, Poland. [e-mail]. Regulatory RNAs as a modulator of aging and lifespan. Frank Slack, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT. [e-mail]. Amino-acid/protein oxidation and aging I Wulf Droge, Immunotec Ressearch, Quebec, Canada. [e-mail]. Or Thomas Squier, Pacific Northwest National Laboratory, Richland, WA. [e-mail]. Selenoprotein and aging Helmut Sies, Dusseldorf, Germany. [e-mail] Oxidation of lipids in aging Rochelle Buffenstein, Department of Biology, City College of the City University of New York, NY. [e-mail]. AGE in aging Sho-ichi Yamagishi, Department of Medicine, Kurume University, Japan. [e-mail]. Section III OxidativeDamage to Subcellular Compartments Oxidative damage to mitochondria and aging Martin Brand, MRC Dunn Human Nutrition MRC, U.K. [e-mail] Or Heinz-Dieter Osiewacz, Johann Wolfgang Goethe University Franfurt, Germany. [e-mail] Oxidative stress and cellular energy failure Pidder Jansen-Duerr, Insbruck, Austria. [e-mail] P66shc regulation in aging and lifespan Pier Giuseppe Pelicci, Milan, Italy. [e-mail] Section IV Oxidative Damage to Organs and Aging Brain: oxidative stress and aging brain Christian Behl, Max Planck Institute of Psychiatry, Munich, Germany. [e-mail] Cardiovascular system Norbert Latruffe, Department of molecular and cell biology, University of Burgndy, France. [e-mail]. Musculoskeletal system and aging Li Li Ji, The Biodynamics Laboratory, University of Wisconsin-Madison, Madison, WI 53706. [e-mail] (We may ask him to focus on the skeletal muscle system instead of the overall "physical activity" at a higher level - see below). Section V Interplay with Other Modulatory Factors of Aging Caloric restriction and oxidative stress I R. S. Sohal, Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90089. Caloric restriction and oxidative stress II Michael Ristow, Department of Human Nutrition, Institute of Nutrition, University of Jena, D-07743 Jena, Germany. Physical activity, oxidative stress and aging I Li Li Ji, The Biodynamics Laboratory, University of Wisconsin-Madison, Madison, WI 53706. [e-mail] Physical activity, oxidative stress and aging II Zsolt Radak, Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary. [e-mail]. Alternatively, Sataro Goro, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. Section VI Nutritional Approaches to Minimize Oxidative Stress and Aging Nutritional supplements and oxidative stress and aging James Joseph, USDA & Tufts University, Boston MA. [e-mail] Garlic, oxidative stress and aging Carmia Borek, Department of Public Health and Family Medicine, Tufts University, Boston, MA. [e-mail] Resveratrol and other plant polyphenols To be determined. Cognitive decline with aging and oxidative stress Norton Milgram, Department of Pharmacology, University of Toronto, Toronto, Canada. [e-mail] Section VII Healthy Aging Strategy Based on Oxidative Stress Protection Healthy aging strategies Bruce Ames, University of California, Berkeley, CA. [e-mail]. And/or Khalid Rahman, School of Biomolecular Sciences, Liverpool John Moores University, UK. [e-mail].

Produkt-Details

• Reihe/Serie: Aging Medicine
• Zusatzinfo: 50 black & white illustrations
• Verlagsort: Totowa, NJ
• Sprache: englisch
• Maße: 193 x 260 mm
• Einbandart: gebunden
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• ISBN-10: 1-60327-548-7 / 1603275487
• ISBN-13: 978-1-60327-548-4 / 9781603275484
• Zustand: Neuware