Struktuelle Untersuchungen an membranassoziierten Proteinen
NMR-Strukturen des HIV-1 Virus Protein U (39-81) und des humanen CD4 (372-433)
Seiten
2008
Forschungszentrum Jülich (Verlag)
978-3-89336-510-4 (ISBN)
Forschungszentrum Jülich (Verlag)
978-3-89336-510-4 (ISBN)
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The transmembrane glycoprotein CD4 (cluster determinant 4) plays a prominent role in
the adaptive immune response . CD4 is displayed primarily on the surface of T helper cells,
but also on subsets of memory and regulatory T lymphocytes . Binding of the lymphocyte
specific tyrosine kinase p56LcK to the cytoplasmic domain of CD4 is crucial for antigen
receptor-mediated signal transduction . The human immunodeficiency virus (HIV) utilizes
CD4 as the main receptor for T-cell invasion . The virus has developed multiple strategies
for down-regulation of CD4 in infected cells . The HIV-1 protein U (VpU) is an accessory
protein responsible for enhancement of virus particle release and downregulation of CD4.
Physical interactions of viral proteins VpU and Nef with the cytoplasmic tail of CD4
initiate a cascade of events leading to degradation of CD4 . Phosphorylation of serines 53
and 57 of VpU plays an essential role in CD4 downregulation.
the adaptive immune response . CD4 is displayed primarily on the surface of T helper cells,
but also on subsets of memory and regulatory T lymphocytes . Binding of the lymphocyte
specific tyrosine kinase p56LcK to the cytoplasmic domain of CD4 is crucial for antigen
receptor-mediated signal transduction . The human immunodeficiency virus (HIV) utilizes
CD4 as the main receptor for T-cell invasion . The virus has developed multiple strategies
for down-regulation of CD4 in infected cells . The HIV-1 protein U (VpU) is an accessory
protein responsible for enhancement of virus particle release and downregulation of CD4.
Physical interactions of viral proteins VpU and Nef with the cytoplasmic tail of CD4
initiate a cascade of events leading to degradation of CD4 . Phosphorylation of serines 53
and 57 of VpU plays an essential role in CD4 downregulation.
| Reihe/Serie | Reihe Gesundheit / Health ; 2 |
|---|---|
| Sprache | deutsch |
| Maße | 170 x 240 mm |
| Einbandart | Paperback |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Schlagworte | DNA • HC/Biologie/Biochemie, Biophysik • HIV-1 • Immunsysteme |
| ISBN-10 | 3-89336-510-9 / 3893365109 |
| ISBN-13 | 978-3-89336-510-4 / 9783893365104 |
| Zustand | Neuware |
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