Molecular Mechanisms of Neurotransmitter Release

Zhao-Wen Wang (Herausgeber)

Buch | Hardcover

347 Seiten

2008 | 2008 ed.
Humana Press Inc. (Verlag)
978-1-934115-38-1 (ISBN)

Infos

Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.

Inhalt

1. The Architecture of the Presynaptic Release Site
R. Grace Zhai
2. Multiple modes of fusion and retrieval at the calyx of Held synapse
Liming He, Benjamin McNeil, and Ling-Gang Wu
3. Roles of SNARE proteins in synaptic vesicle fusion
Mark T. Palfreyman and Erik M. Jorgensen


4. Roles and sources of calcium in synaptic exocytosis


Zhao-Wen Wang, Bojun Chen, Qian Ge
5. Regulation of presynaptic calcium channels
Allen W. Chan and Elise F. Stanley
6. Synaptotagmin: transducing Ca2+-binding to vesicle fusion
Carin Loewen and Noreen Reist


7. Functional interactions between the SNARE regulators UNC-13, tomosyn and UNC-18


Robby M. Weimer and Janet E. Richmond
8. Roles of the ELKS/CAST family and SAD kinase in Neurotransmitter Release
Toshihisa Ohtsuka and Yoshimi Takai
9. The role of potassium channels in the regulation of neurotransmitter release.
Laurence O. Trussell and Michael T. Roberts
10. Modulation of neurotransmitter release and presynaptic plasticity by protein phosphorylation
Zu-Hang Sheng
11. Synaptic Vesicle Endocytosis
Liesbet Smitz and Patrik Verstreken
12. Lipids and secretory vesicle exocytosis
Shona L. Osborne and Frederic A. Meunier
13. Neurotransmitter reuptake and synaptic vesicle refilling
Richard J. Reimer*, Kimberly A. Zaia, and Hiroaki Tani
14. Regulation of neurotransmitter release by presynaptic receptors
Matthew Frerking, and Joyce Wondolowski
15. Trans-synaptic regulation of presynaptic release machinery in central synapses by cell adhesion molecules
Kensuke Futai and Yasunori Hayashi
16. Differential regulation of small clear vesicles and large dense-core vesicles
Tao Xu and Pingyong Xu

Produkt-Details

• Reihe/Serie: Contemporary Neuroscience
• Zusatzinfo: 2 Tables, black and white; XIII, 347 p.
• Verlagsort: Totowa, NJ
• Sprache: englisch
• Maße: 155 x 235 mm
• Gewicht: 711 g
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• ISBN-10: 1-934115-38-X / 193411538X
• ISBN-13: 978-1-934115-38-1 / 9781934115381
• Zustand: Neuware