Blick ins Buch

The Role of Wnt Signalling in the Development of Somites and Neural Crest

Corina Schmidt, Imelda McGonnell, Steve Allen, Ketan Patel (Autoren)

Buch | Softcover

X, 64 Seiten

2008 | 2008
Springer Berlin (Verlag)
978-3-540-77726-7 (ISBN)

Lese- und Medienproben

Blick ins Buch (midvox)

Artikel merken

1 Introduction 1. 1 Wnts and Development The f amily of Wnt genes consists of at least 19 members in vertebrates. Wnts ha v e multiple roles during normal development and aetiology of diseases (Wodarz and Nusse 1998; Moon et al. 2002, 2004). These genes encode for glycoproteins that are released in the intercellular space, acting as intercellular mediators (Moon et al. 1997). By binding to their special receptors, the Frizzled (Fz) receptors, they are able to activate at least three different pathways: the canonical, the non-canonical and the Ca 2+ pathway (Fig. 1 ). The Wnt family has been subdivided, using functional assays, into at least two subclasses. In Xenopus , Wnt1, Wnt3a and Wnt8 are able to induce axis duplication in embryos, whereas Wnt4, Wnt5a and Wnt11 cannot (Du et al. 1995). Those Wnts that are able to induce axis duplication are thought to act canonically; those who cannot are thought to act non-canonically. In the literature, therefore, some Wnts are called canonical Wnts while others are called n- cano nical Wnts, suggesting that a special Wnt always activates the same signalling pathway. It is unlikely that the specificity dictating cellular responses resides solely in the Wnt ligands because no one has reported sequence or structural motifs in Wnts that predict their activities in these cellular and embryonic assays.

1. Introduction.- 1.1 Wnts and development.- 1.2. Somite formation.- 1.3. Induction, delamination and migration of neural crest.- 1.4. Outline of research plan.- 2. Material and methods.- 3. Results.- 3.1 Wnt6 and somitogenesis.- 3.2 The regulation of cNkd1 expression.- 3.3 Wnt6 and the neural crest.- 4. Discussion.- 5. Summary.- 7. References.- 8. Acknowledgements.- Subject index.

Erscheint lt. Verlag	12.6.2008
Reihe/Serie	Advances in Anatomy, Embryology and Cell Biology
Zusatzinfo	X, 64 p. 15 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	130 g
Themenwelt	Medizin / Pharmazie ► Studium
Themenwelt	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	cNkd1 expression • Development • Hardcover, Softcover / Medizin/Nichtklinische Fächer • HC/Medizin/Nichtklinische Fächer • Migration • neural crest induction • neural crest production • Regulation • somitogenesis
ISBN-10	3-540-77726-1 / 3540777261
ISBN-13	978-3-540-77726-7 / 9783540777267
Zustand	Neuware