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Natural Compounds as Drugs, Volume II

Frank Petersen, René Amstutz (Herausgeber)

Buch | Hardcover

X, 428 Seiten

2008 | 2008
Springer Basel (Verlag)
978-3-7643-8594-1 (ISBN)

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The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.

Activation of fungal silent gene clusters: A new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs — pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin — an innovative cornerstone for anti-malaria therapy.

Erscheint lt. Verlag	13.3.2008
Reihe/Serie	Progress in Drug Research
Zusatzinfo	X, 428 p. 212 illus., 27 illus. in color.
Verlagsort	Basel
Sprache	englisch
Maße	170 x 250 mm
Gewicht	1270 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	Bacteria • Cancer • chemical space • Drug • drug discovery • Drug research • enzymes • Fermentation • high throughput screening • lead • natural product • pharmacology • Pharmakologie • receptor • Research • Screening • synthesis
ISBN-10	3-7643-8594-4 / 3764385944
ISBN-13	978-3-7643-8594-1 / 9783764385941
Zustand	Neuware