Pharmacology of Neurotransmitter Release
Springer (Verlag)
978-3-540-74804-5 (ISBN)
- Analyses the molecular events of exocytosis
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis.
The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book’s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors.
The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.
Thomas Christian Südhof, geb. 1955 in Göttingen, ist Professor an der Stanford University und leitet das dortige Südhof Laboratorium an der Medical School. 2013 wurde ihm gemeinsam mit James Rothman und Randy Schekman der Nobelpreis für Physiologie oder Medizin zuerkannt.
Overview. Pharmacology of Neurotransmitter Release: Measuring Exocytosis. Preysnaptic Calcium Channels: Structure, Regulators, and Blockers. Pharmacology of Neurotansmitter Transport into Secretory Vesicles. Core Proteins of the Secretory Machinery. Presynaptic Neurotoxins with Enzymatic Activities. a-Latrotoxin and Its Receptors. Presynaptic signaling by heterotrimeric G-proteins. Presynaptic Receptors for Acetylcholine, and Adrenaline/Noradrenaline. Presynaptic receptors for dopamine, histamine and serotonin. Presynaptic Adenosine and P2Y Receptors. Presynaptic Metabotropic Glutamate and GABAB Receptors. Presynaptic Neuropeptide Receptors. Presynaptic Modulation by Endocannabinoids. Presynaptic Ionotropic Receptors. NO/cGMP-Dependent Modulation of Synaptic Transmission. Therapeutic Use of Release-Modifying Drugs.
| Erscheint lt. Verlag | 18.12.2007 |
|---|---|
| Reihe/Serie | Handbook of Experimental Pharmacology ; 184 |
| Zusatzinfo | 68 illus. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 943 g |
| Einbandart | gebunden |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Pharmazie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Schlagworte | adenosine • Cannabinoid • dopamine • Exocytosis • Neurotransmitter Release • Presynaptic autoreceptors • synaptic plasticity |
| ISBN-10 | 3-540-74804-0 / 3540748040 |
| ISBN-13 | 978-3-540-74804-5 / 9783540748045 |
| Zustand | Neuware |
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