Novartis Foundation Symposium 125 – Junctional Complexes of Epithelial Cells

C Ciba Foundation (Autor)

Software / Digital Media

284 Seiten

2007
Wiley-Blackwell (Hersteller)
978-0-470-51340-8 (ISBN)

Keine Verlagsinformationen verfügbar

Artikel merken

Epithelial cells cover the outer and inner surfaces of the body, forming a selective polarized barrier between the intercellualar space and the 'external' world. Linking the cells of this continuous layer and contributing to epithelial organization and function are specialized membrane domains--desmosomes, gap junctions, and occluding junctions. The contributors to this multidisciplinary symposium volume explore the nature of such junctional structures, focusing on the molecular organization and diversity of their constituent proteins, their formation and control, and interactions with ions and cytoskeletal elements. The physiological significance of cell-cell interaction in epithelia is considered, with reference to cell adhesion, barrier formation and intercellular communication, and to the functional implications for tissue architecture, embryonic development, morphogenesis and carcinogenesis.

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Chairman's Introduction (M. Stoker). On the Molecular Organization, Diversity and Functions of Desmosomal Proteins (M.S. Steinberg & et al). The Desmosomal Plaque and the Cytoskeleton (W.W. Franke & et al). Localization of Desmosomal Proteins. Gap Junction Structure and the Control of Cell-to-Cell Communication (P.N.T. Unwin). Molecular Structure of the Gap Junctional Channel (M.E. Finbow, & et al). Sequence Diversity of Gap Junction Proteins (J.P. Revel & et al). Topology of Gap Junction Protein and Channel Function (N.B. Gilula). Patterns of Junctional Communication in Animal Tissues (J. Pitts, & et al). The Use of Antibodies to Gap Junction Protein to Explore the Role of Gap Junctional Communication During Development (A. E. Warner). The Role of Uvomorulin in the Formation of Epithelial Occluding Junctions (B. Gumbiner & K. Simons). Barrier Function of Tight Junctions. Tight Junction Proteins. Epigenetic Rules for Expression of Cell Adhesion Molecules During Morphogenesis (G M. Edelman). Factors Affecting Epithelial Interactions (M. Stoker & E. Gherardi). Index. Subject Index.

Erscheint lt. Verlag	28.9.2007
Verlagsort	Hoboken
Sprache	englisch
Maße	135 x 257 mm
Gewicht	580 g
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	0-470-51340-3 / 0470513403
ISBN-13	978-0-470-51340-8 / 9780470513408
Zustand	Neuware