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Retrotransposition, Diversity and the Brain

Fred H. Gage (Herausgeber)

Buch | Hardcover

XII, 123 Seiten

2007 | 2008
Springer Berlin (Verlag)
978-3-540-74965-3 (ISBN)

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The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learned from the discovery of the mechanism for diversityinthe immune system maybe usefultothe investigation ofthe mechanism of diversity in neurons.

Telomeres and Telomerase in Human Health and Disease.- Molecular and Circuit Mechanisms for Hippocampal Learning.- Retrotransposons - Natural and Synthetic.- Ancient Retrotransposons as Possible Remnants of the Primitive RNPWorld.- Human Diversity and L1 Retrotransposon Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential.- From the "RNAWorld" to Brain Complexity: Generation of Diversity.- Endogenous Retroviruses and Human Neuropsychiatric Disorders.- Is Psychosis Due to Retroviral/Retrotransposon Integration Close to the Cerebral Dominance Gene?.- Microcephalies and DNA Repair.

Erscheint lt. Verlag	5.12.2007
Reihe/Serie	Research and Perspectives in Neurosciences
Zusatzinfo	XII, 123 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	DNA • DNA repair • endogenous retroviruses • genes • microcephalies • neuropsychiatric disorders • retrotransposons • Telomere • Telomeres
ISBN-10	3-540-74965-9 / 3540749659
ISBN-13	978-3-540-74965-3 / 9783540749653
Zustand	Neuware