Richard Garratt studied Biochemistry at the University of London (UK), receiving a PhD in protein crystallography from Birkebeck College, London, in 1989. He then moved to the University of Sao Paulo (Brasil), where he was appointed Professor in 1996. Professor Garratt heads the crystallography group at the San Carlos Institute of Physics, focusing his research on protein structure determination and rational drug design. He is also the inventor of a widely acclaimed protein structure modeling kit for educational purposes. Christine Orengo studied Physics at the Universities of Bristol and Aberdeen (UK), receiving a PhD in Biochemistry from University College, London in 1984. She then became a MRC fellow and was later appointed Professor of Bioinformatics at University College. Together with Janet Thornton, Professor Orengo has developed the CATH protein structure database that is widely used to compare and identify evolutionarily related proteins.
INSIDE FACINGThe main table displays 86 stuctural domains, organized into four major (alpha proteins, beta proteins, alpha/beta proteins, knots and fibers) and 26 minor architectural classes (such as sandwich, barrel, horseshoe, orthogonal bundle etc.).For each domain, a representative structure is shown alongside structural and functional information for the fold group.The abundance of each fold group in the currently sequenced more than 500 genomes is given, with the 10 most abundant "superfolds" highlighted.OUTSIDE FACINGA satellite table of oligomeric proteins depicts 37 oligomer architectures, ordered according to their highest order rotation axis. For each class, a representative structure is displayed, along with structural and functional information on the class.Also on the chart is a summary of 10 basic secondary structure topologies (shown in a 2D representation) and of the 12 most important three-dimensional structural motifs such as HTH, EF hand, HLH, Zn finger, P-loop, Greek key etc.
"The 'periodic table' of proteins illustrates the beauty, diversity, and complexity of proteins in one place. It is a remarkable teaching and learning tool."(Donald Voet, author of the textbooks "Biochemistry" and "Fundamentals of Biochemistry")"The ideal tool to understand and to teach the principles of protein structure, and beautifully designed. I wholeheartedly recommend it."(Robert Huber, Winner of the 1988 Nobel Prize in Chemistry)
| Erscheint lt. Verlag | 21.11.2007 |
|---|---|
| Sprache | englisch |
| Maße | 215 x 280 mm |
| Gewicht | 55 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Schlagworte | Biochemie • biomedical engineering • Biomedizintechnik • Biowissenschaften • Chemie • Chemistry • Computational Chemistry & Molecular Modeling • Computational Chemistry & Molecular Modeling • Computational Chemistry u. Molecular Modeling • Life Sciences • Molecular Evolution • Molekularbiologie • Molekulare Evolution • Protein • Proteine • Protein / Eiweiß • Protein Engineering • Protein-Engineering • Protein Science • structural biology • Strukturbiologie |
| ISBN-10 | 3-527-31963-8 / 3527319638 |
| ISBN-13 | 978-3-527-31963-3 / 9783527319633 |
| Zustand | Neuware |
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