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Sparking Signals

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

Gottfried Baier, Burkhart Schraven, Ulrich Zügel, Arne Bonin (Herausgeber)

Buch | Hardcover

XIV, 187 Seiten

2008
Springer Berlin (Verlag)
978-3-540-73500-7 (ISBN)

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The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. In this book, well known experts present their most recent findings on the fast developing kinase field. It will be of interest to basic researchers and the pharmaceutical industry.

Proteomics-bases Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T-Lymphocytes.- Molecular and Systems-Biology Approaches to Define Signaling Pathways in Lymphocytes.- Solving the IRAK-4 Enigma. Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting and Regulating PAMPS.- Migration, Cell-Cell Interaction and Adhesion in the Immune System.- The Role of Diacylglycerol Kinases in T Cell Anergy.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.

Erscheint lt. Verlag	11.4.2008
Reihe/Serie	Ernst Schering Foundation Symposium Proceedings
Zusatzinfo	XIV, 187 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	473 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	cellular signalling • Drug Finding • Immune-modulation • Kinase Inhibitors • Metabolism • Proteomics • Translation
ISBN-10	3-540-73500-3 / 3540735003
ISBN-13	978-3-540-73500-7 / 9783540735007
Zustand	Neuware