Intramembrane-Cleaving Proteases (I-CLiPs)

Nigel M. Hooper, Uwe Lendeckel (Herausgeber)

Buch | Hardcover

142 Seiten

2007
Springer-Verlag New York Inc.
978-1-4020-6310-7 (ISBN)

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In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.

The Site-2 Protease at Ten.- Signal Peptide Peptidases.- GXGD-Type Intramembrane Proteases.- Rhomboid Intramembrane Serine Proteases.- Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae.- ?-Secretase And Alzheimer’S Disease.- ?-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling.

Erscheint lt. Verlag	26.7.2007
Reihe/Serie	Proteases in Biology and Disease ; 6
Zusatzinfo	IX, 142 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	1-4020-6310-5 / 1402063105
ISBN-13	978-1-4020-6310-7 / 9781402063107
Zustand	Neuware