Solid–Phase Synthesis & Combinatorial Technologies (Obook)
Seiten
2002
John Wiley & Sons Inc (Hersteller)
978-0-471-22039-8 (ISBN)
John Wiley & Sons Inc (Hersteller)
978-0-471-22039-8 (ISBN)
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Looks at solid phase synthesis and advances in combinatorial chemistry and technologies. This work provides an overview of the most important aspects of solid phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It also features a detailed bibliography of more than 1,700 relevant sources.
This is a unique, integrated look at solid phase synthesis and advances in combinatorial chemistry and technologies. The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines.
Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, "Solid Phase Synthesis and Combinatorial Technologies": surveys the most recent developments in SPS and combinatorial chemistry; explains the entire process, from determining the need for a library to the details necessary for synthesis of the library; discusses choice of format, size, and the rationale behind the design of each synthetic step; surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries; employs a large number of examples to illustrate important concepts; includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis; describes the quality control and activity screening of combinatorial libraries for various applications; and features a detailed bibliography of more than 1,700 relevant sources.
This is a unique, integrated look at solid phase synthesis and advances in combinatorial chemistry and technologies. The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines.
Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, "Solid Phase Synthesis and Combinatorial Technologies": surveys the most recent developments in SPS and combinatorial chemistry; explains the entire process, from determining the need for a library to the details necessary for synthesis of the library; discusses choice of format, size, and the rationale behind the design of each synthetic step; surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries; employs a large number of examples to illustrate important concepts; includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis; describes the quality control and activity screening of combinatorial libraries for various applications; and features a detailed bibliography of more than 1,700 relevant sources.
PIERFAUSTO SENECI, PhD, is Associate Director of Chemistry at the Glaxo Wellcome Medicines Research Centre, Verona, Italy.
Solid Phase Synthesis: Basic Principles. Solid Phase Synthesis: Oligomeric Molecules. Solid Phase Synthesis: Small Organic Molecules. Combinatorial Technologies: Basic Principles. Synthetic Organic Libraries: Library Design and Properties. Synthetic Organic Libraries: Solid Phase Discrete Libraries. Synthetic Organic Libraries: Solid Phase Pool Libraries. Synthetic Organic Libraries: Solution Phase Libraries. Applications of Synthetic Libraries. Biosynthetic Combinatorial Libraries. Materials and Polymeric Combinatorial Libraries. Index.
| Erscheint lt. Verlag | 25.4.2002 |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Gewicht | 10 g |
| Themenwelt | Naturwissenschaften ► Chemie |
| ISBN-10 | 0-471-22039-6 / 0471220396 |
| ISBN-13 | 978-0-471-22039-8 / 9780471220398 |
| Zustand | Neuware |
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