Atropisomerism in Asymmetric Organic Synthesis (eBook)

Challenges and Applications

Shinobu Takizawa, Mohamed S. H. Salem (Herausgeber)

eBook Download: PDF

2024
355 Seiten
Wiley-VCH (Verlag)
978-3-527-84423-4 (ISBN)

Infos

Unique overview of the recent synthetic methodologies of the atropisomeric molecules and their numerous practical applications

Atropisomerism in Asymmetric Organic Synthesis: Challenges and Applications presents new methodologies, strategies, unique catalysts, and solutions to challenges in the area of oxidative heterocoupling. After a general introduction for the concept of atropisomerism, this book focuses on the recent advances in the atroposelective synthesis of axially chiral compounds and how these advances had a significant impact on several applications in asymmetric catalysis and the synthesis of natural products.

The book covers the recent examples of metal-catalyzed (Cu, Fe, Ru, V, etc) and organocatalyzed atroposelective syntheses of axially chiral compounds using diverse approaches, including cross-coupling reactions, ring-opening reactions, formation of new aromatic rings, and desymmetrization via functional group transformation. The impact of these efficient strategies on various applications in asymmetric catalysis, total synthesis of natural products, synthesis of polycyclic heteroaromatics (PHAs), and the drug industry is also addressed.

Edited by two highly qualified academics, Atropisomerism in Asymmetric Organic Synthesis explores sample topics including:

• Iron- and ruthenium-catalyzed atroposelective synthesis of axially chiral compounds and the catalytic applications of multinuclear zinc complexes with axially chirality
• Vanadium-catalyzed atroposelective coupling of arenols and application in the synthesis of polycyclic heteroaromatics PHAs
• Mechanisms of atroposelective Suzuki-Miyaura coupling towards axially chiral biaryls and organocatalytic enantioselective formation of atropisomers
• Synthesis of atropisomers via enantioselective ring-opening reactions and the impact of axially chiral ligands and catalysts derived from atropisomeric binaphthyl structures
• Binaphthyl-based chiral DMAP derivatives in enantioselective transformations and catalytic atroposelective oxidative coupling in natural product synthesis

Enabling readers to comprehensively understand the development history, research status, and potential of atropisomeric synthesis, Atropisomerism in Asymmetric Organic Synthesis is an essential, up-to-date reference for researchers and scientists in the field.

Shinobu Takizawa, PhD, is Professor at SANKEN, Osaka University, Japan. His current research focuses on developing environmentally friendly organic synthetic processes.

Mohamed S. H. Salem, PhD, is Assistant Professor at SANKEN, Osaka University, Japan. His current research focuses on developing green synthetic approaches for the bottom-up synthesis of functionalized small organic molecules with various material-based applications.

Produkt-Details

• Erscheint lt. Verlag: 7.10.2024
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Schlagworte: Asymmetric catalysis • Atropisomerism • atroposelective synthesis • axially chiral compounds • dmap derivatives • drug development • drug industry • oxidative heterocoupling • phas • poly-hydroxy-alkanoates • synthesis of natural products
• ISBN-10: 3-527-84423-6 / 3527844236
• ISBN-13: 978-3-527-84423-4 / 9783527844234