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Chemokines and Viral Infection

Thomas E. Lane (Herausgeber)

Buch | Hardcover
XI, 160 Seiten
2006 | 2006
Springer Berlin (Verlag)
978-3-540-29207-4 (ISBN)

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Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.

Functional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System.- Cytokine and Chemokine Networks: Pathways to Antiviral Defense.- Herpes Simplex Virus and the Chemokines That Mediate the Inflammation.- Influence of Proinflammatory Cytokines and Chemokines on the Neuropathogenesis of Oncornavirus and Immunosuppressive Lentivirus Infections.- HIV-1 Coreceptors and Their Inhibitors.- A Viral Conspiracy: Hijacking the Chemokine System Through Virally Encoded Pirated Chemokine Receptors.

Erscheint lt. Verlag 2.3.2006
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo XI, 160 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 370 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Schlagworte antiviral defense • Cell • Chemokine • Cytokine • cytokines • Diseases • G protein-coupled receptors • Herpes simplex virus • HIV-1 coreceptors • immunosuppressive lentivirus infection • Infection • Infections • Infektion / Infektionskrankheiten • inflammation • Lymphocytes • Oncornavirus • pathogenesis • proinflammatory cytokines • Protein • proteins • Viral Infection • Virus
ISBN-10 3-540-29207-1 / 3540292071
ISBN-13 978-3-540-29207-4 / 9783540292074
Zustand Neuware
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