Nanotechnology in Therapeutics (eBook)

Basics and Trends

Costas Demetzos (Autor)

eBook Download: EPUB

2024 | 1. Auflage
304 Seiten
Wiley (Verlag)
978-1-394-27407-9 (ISBN)

Infos

Nanotechnology in Therapeutics

Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications

Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book.

The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets.

Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on:

• Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayers
• The DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticles
• Liposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimers
• Issues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics

With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.

Costas Demetzos is Professor of Pharmaceutical Nanotechnology at the National and Kapodistrian University of Athens. Currently, Prof. Demetzos serves as Director of the Laboratory of Pharmaceutical Technology, and since 2008 he serves as President of the Hellenic Pharmaceutical Society (HPS). His research interests include pharmaceutical nanotechnology, nanomedicine, and thermodynamics.

Textauszug

List of Abbreviations

ACE2

Angiotensin‐converting enzyme 2

ADME

Absorption distribution metabolism and excretion

aDDnS

Advanced drug delivery nanosystems

AFM

Atomic force microscopy

APC

Antigen presenting cells

AI

Artificial intelligence

AIDS

Acquired immunodeficiency syndrome

ANN

Artificial neural network

ATMP

Advanced therapy medicinal product

ATP

Adenosine triphosphate

AuNR

Gold nanorod

BCD

Biological complex drugs

CAT

Committee for Advanced Therapies

CBER

Center for Biological Evaluations and Research

CDER

Center for Drug Evaluation and Research

CDRH

Center for Device and Radiological Health

c‐DOPE

citraconyl‐DOPE (1,2‐dioleoyl‐3‐phosphatidylethanotamine)

CHMP

Committee for Medicinal Products for Human Use

CLN

Core–shell lipid nanoparticle

CPP

Critical packing parameter

CRISPR

Clustered regularly interspaced short palindromic repeats

Cryo‐AFM

Cryogenic atomic force microscopy

Cryo‐TEM

Cryo‐transmission electron microscopy

CQAs

Critical quality attributes

CVD

Cardiovascular disease

CVM

Center for Veterinary Medicine

DAPE

Diacetylenic phosphatidylethanolamine

ΔCpmax

Change of maximum heat capacity

ΔΗ

Change in enthalpic content

ΔT1/2

Change in transition's width at half peak height

DLin‐MC3‐DMA

(6Z,9Z,28Z,31Z)‐Heptatriaconta‐6,9,28,31‐tetraen‐19‐yl‐4‐(dimethyl‐amino)butanoate

DLVO

Derjaguin, Landau, Verwey, and Overbeek

DL

Deep learning

DLS

Dynamic light scattering

DMA

Dynamic mechanical analysis

DMPC

Dimyristoylphosphatidylcholine

DMPG

Dimyristoylphosphatidylglycerol

DOPC

Dioleoyl‐phosphatidylcholine

DOPE

Dioleoyl‐phosphatidylethanolamine

DODMA

1,2‐Dioleyloxy‐3‐dimethylaminopropane

DOTAP

1,2‐Dioleoyl‐3‐(trimethylammonium)‐propane

DOTMA

N‐1‐(2,3‐dioleoyloxy)‐propyl‐N,N,N‐trimethylammonium

DPH

Diphenylhexatriene

DPPC

Dipalmitoyl‐phosphatidylcholine

DPPE

Dipalmitoyl‐phosphatidylethanolamine

DPPG

Dipalmitoyl‐phosphatidylglycerol

DQA

Deqalinium

DSPE‐PEG

Distearoyl‐phosphatidylethanolamine‐polyethylene glycol

DSPC

Distearoyl‐phosphatidylcholine

DSC

Differential scanning calorimetry

DT

Digital therapeutic

DTA

Differential thermal analysis

DTG

Differential thermogravimetry

EAPP

European agency for pharmaceutical products

EC

European Commission

EEA

European Economic Area

EFSA

European Food Safety Authority

EFTA‐EEA

European Free Trade Associations‐European Economic Area

EGA

Evolved gas analysis

EHF

Ebola hemorrhagic fever

ELS

Electrophoretic light scattering

EM

Electronic microscopy

EMA

European Medicine Agency

EMEA

European Agency for the Evaluation of Medicinal Products

EPAR

European Public Assessment Report

EPC

Egg‐phosphatidylcholine

EPR

Enhanced permeability and retention

ETP

European technology platform

ETPN

European technology platform on nanomedicine

EU

European Union

EVD

Ebola virus disease

FDA

Food and Drug Administration

FFEM

Freeze fracture electron microscopy

FF‐TEM

Freeze‐fracture transmission electron microscopy

FTIR

Fourier transform infrared spectroscopy

G

Gibbs free energy

GDPR

General data protection regulation

GI

Gastrointestinal

GMO

Glyceryl monooleate

GMP

Good manufacturing practice

GPI

Glycosylphosphatidylinositol

GTMP

Gene therapy medicinal product

GUV

Giant unilamellar liposome

HHV

Human herpes virus

HIV

Human immunodeficiency virus

HLA

Human leukocyte antigen

HSPC

Hydrogenated soy phosphatidylcholine

ICH

International Conference for Harmonization

ICTAC

International Confederation for Thermal Analysis and Calorimetry

IMM

Inner mitochondrial membrane

IMS

Intermembrane space

IND

Investigational new drug application

ITF

Innovation task force

IUPAC

International Union of Pure and Applied Chemistry

KET

Key enabling technologies

LC

Liquid crystal

LFM

Lateral force microscopy

LTL

Ligand‐targeted liposome

LNP

Lipid nanoparticle

LUV

Large unilamellar vesicle

LVEM

Low voltage electron microscopy

MAA

Marketing authorization application

MAS 13C‐NMR

Magic angle spinning 13C‐nuclear magnetic resonance

MDM

Material data mining

MHM

Modified heating method

MPEG‐DSPE

Methoxypolyethylene glycol‐distearoyl‐phosphatidylcholine

MPEG 2000‐DSPE

Methoxypolyethylene glycol 2000‐distearoyl‐phosphatidylcholine

MPP

Mitochondria penetrating peptide

MPS

Mononuclear phagocyte system

MRI

Magnetic resonance imaging

MLV

Multilamellar vesicle

mtDNA

mitochondrial DNA

MVL

Multivesicular liposome

MVV

Multivesicular vesicle

MLL

Multilamellar liposomes

NASBA

Nucleic acid sequence‐based amplification

NBCD

Non‐biological complex drugs

NCI

National Cancer Institute

NDA

New drug application

NFAS

Non‐flame atomic spectroscopy

NHT

New health technology

NIR

Near infrared

NLC

Nanostructured lipid carriers

NMR

Nuclear magnetic resonance

NNI

National nanotechnology initiative

NP

Nanoparticle

NPLD

Non‐PEGylated liposome doxorubicin

OLV

Oligolamellar vesicle

OMM

Outer mitochondrial membrane

OTC

Over the counter

PAMAM

Poly(amidoamine)

PC

Phosphatidylcholine

PCR

Polymerase chain reaction

PCS

Photon correlation spectroscopy

PDI

Polydispersity index

PDT

Photodynamic therapy

PE

Phosphatidylethanolamine

PEO

Polyethylene oxide

PEO‐PMPS

Poly(ethylene oxide)‐poly(methylphenylsilane)

PET

Positron emission tomography

PEG

Polyethylene glycol

PEG‐DMG

Polyethyleneglycol‐dimyristoyl glycerol

PLGA

Poly(lactic‐co‐glycolic acid)

PNP

Polymeric nanoparticles

PPP

Public–private partnership

PPI

Protein–protein interaction

PRIME

Priority medicines program

QSAR/QSPR

Quantitative structure–activity/property relationship

RAS protein

Rat sarcoma virus protein

RBD

Receptor binding domain

REM

Reflection electron microscopy

RES

Reticuloendothelial system

ROS

Reactive oxygen species

RT‐PCR

Reverse transcription polymerase chain reaction

sCTMP

Somatic cell therapy medicinal...

Produkt-Details

• Erscheint lt. Verlag: 22.7.2024
• Mitarbeit: Herausgeber (Serie): Dennis Douroumis, Alfred Fahr, Juergen Siepmann, Martin J. Snowden, Vladimir P. Torchilin
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie
• ISBN-10: 1-394-27407-6 / 1394274076
• ISBN-13: 978-1-394-27407-9 / 9781394274079