Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics

Buch | Softcover

IX, 192 Seiten

2024 | 2023
Springer International Publishing (Verlag)
978-3-031-35809-8 (ISBN)

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This volume provides a comprehensive and up-to-date overview of the various aspects of Lassa virus (LASV), the causative agent of Lassa fever, a frequently fatal zoonotic disease endemic to West Africa. Compiled by world-leading experts in the field, this book provides an introduction to the 50-year history of Lassa fever research, the genetic diversity of LASV, and its geographic distribution. Subsequent chapters focus on the ecology and epidemiology of LASV, discussing in-depth the interactions of the virus with its hosts - multimammate mice and other rodents - and the interactions between these animal reservoirs and humans. The book also details the many advances in understanding the structural biology and replication of LASV, including new insights into the structure and function of its proteins. These advances in the basic understanding of LASV biology have enabled the development of LASV countermeasures, including sensitive and specific diagnostic assays. Promising drugcandidates, including monoclonal antibodies, and vaccines are also discussed. A final and essential chapter addresses current and future clinical practice for clinical management of Lassa fever.
This volume is intended for researchers and clinicians in the fields of virology, epidemiology, and microbiology.

Dr. Robert F. Garry is the manager of a partnership of scientists striving to deepen understanding of emerging pathogens such as Lassa virus. His efforts have led to the production of Lassa fever diagnostics and development of improved research and clinical infrastructure in West Africa. Here, he draws on those experiences to summarize essential knowledge about Lassa virus and to foreshadow important advances that are coming to control and treat of this important human pathogen.

50 years of Lassa fever research.- Lassa Virus Genetics.- Ecology of Lassa virus.- Epidemiology of Lassa Fever.- Lassa virus countermeasures.- Lassa virus structural biology and replication.- Lassa Fever Natural History and Clinical Management.

Erscheinungsdatum	19.07.2024
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IX, 192 p. 32 illus., 31 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	contact tracing • Healthcare Infrastructure • international health crises • Kenema Government Hospital • Rodent control • Viral hemorrhagic fever
ISBN-10	3-031-35809-0 / 3031358090
ISBN-13	978-3-031-35809-8 / 9783031358098
Zustand	Neuware