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Reconciling the Debate: Evidence for Caveolin-1 in Human Ventricular Cardiomyocytes

(Autor)

Buch | Softcover
130 Seiten
2024
tredition (Verlag)
978-3-384-25643-0 (ISBN)
CHF 39,95 inkl. MwSt
plasma membrane as a protective mechanism.29 In the heart, a high density of caveolae have been shown at the plasma membrane, increasing the surface area up to 2-fold.22,30,31,32 Indeed, disruption of caveolar biogenesis in cardiac muscles can lead to cell damage and compensatory hypertrophy.33 Caveolae exist as single pits with a characteristic omega-shaped structure at the cell surface,22 while association of multiple caveolae was proposed to contribute to T-tubules biogenesis in postnatal muscle cells5, or to multi-lobed caveolar structures called rosettes34. CAV3 knock-out in mice resulted in a complete loss of caveolae and decreased T-tubule density.35 It was proposed, that the actin cytoskeleton regulates the organization of caveolae such that actin polymerization increases caveolae abundance.36 Furthermore, the actin cytoskeleton was proposed to be involved in caveolae endocytosis and recycling.37,38 The association of caveolae with actin filaments was documented by electron microscopy in fibroblasts39, epithelial cells40 and muscle cells29.

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Erscheint lt. Verlag 10.6.2024
Verlagsort mm road
Sprache englisch
Maße 155 x 234 mm
Gewicht 230 g
Themenwelt Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Humanbiologie
Schlagworte cardiac muscle cells • cardiovascular physiology • Cardiovascular Research • Caveolae • Caveolin-1 • Cell Biology • cellular mechanisms • Heart disease • human ventricular cardiomyocytes • myocyte function
ISBN-10 3-384-25643-3 / 3384256433
ISBN-13 978-3-384-25643-0 / 9783384256430
Zustand Neuware
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