Basic Clinical Radiobiology

Michael C. Joiner, Albert van der KogeJ. l (Herausgeber)

Buch | Hardcover

346 Seiten

2025 | 6th edition
CRC Press (Verlag)
978-1-032-24380-1 (ISBN)

Noch nicht erschienen (ca. Dezember 2025)
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The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.

Michael C. Joiner, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA. Albert J. van der Kogel, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.

Preface
About the editors
List of contributors
Glossary

1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation – how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy.

Index

Erscheint lt. Verlag	23.12.2025
Zusatzinfo	48 Tables, black and white; 175 Line drawings, color; 6 Line drawings, black and white; 13 Halftones, color; 1 Halftones, black and white; 188 Illustrations, color; 7 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	210 x 280 mm
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
ISBN-10	1-032-24380-5 / 1032243805
ISBN-13	978-1-032-24380-1 / 9781032243801
Zustand	Neuware