Fluorous Parallel and Combinatorial Synthesis
Iowa State University Press (Verlag)
978-0-8138-1552-7 (ISBN)
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This book forms a highly practical and industrially focused guide to fluorous chemistry syntheses, which are being widely explored as substitutes for traditional reactions and combinatorial methods in many companies. It introduces fluorous synthesis and makes comparisons with conventional solution-phase and solid-phase syntheses. This book highlights strategies for implementing fluorous technology in parallel and combinatorial syntheses. It describes applications for medicinal chemistry. It gives case studies of library synthesis using different fluorous techniques. It also outlines new representative experimental procedures throughout the text.
Wei Zhang is a former student and business partner of Dennis Curran, of the University of Pittsburgh, a leader in fluorous chemistry. Wei is the research director of Fluorous Technologies, a company devoted to understanding and commercializing advances in fluorous chemistry.
1. Introduction.Historic overview.Fluorous compounds.Fluorous solvents.Biphasic partitions.2. Fluorous analytical and separation methods.Liquid-liquid extraction.Solid-phase extraction.Chromatography.High-throughput purification.3. Fluorous synthesis.Fluorous reaction systems.Fluorous tagging strategies.Light and heavy fluorous synthesis.Comparison with conventional solution-phase and solid-phase synthesis.4. Fluorous parallel synthesis.Fluorous catalysts.Fluorous reagents.Fluorous scavengers.Fluorous protecting groups and tags.Fluorous building blocks.5. Fluorous combinatorial synthesis.Mixture synthesis.Multi-component reactions.Microwave reactions.Solid-phase reactions.Peptide synthesis.Oligosaccharide synthesis.6. New fluorous technologies.Triphasic synthesis.Reaction and separation in supercritical CO-2.Fluorous green chemistry
| Erscheint lt. Verlag | 18.12.2009 |
|---|---|
| Zusatzinfo | 45 illustrations |
| Verlagsort | Arnes, AI |
| Sprache | englisch |
| Maße | 152 x 229 mm |
| Themenwelt | Naturwissenschaften ► Chemie ► Anorganische Chemie |
| ISBN-10 | 0-8138-1552-5 / 0813815525 |
| ISBN-13 | 978-0-8138-1552-7 / 9780813815527 |
| Zustand | Neuware |
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