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Statistical Monitoring of Clinical Trials - Lemuel A. Moyé

Statistical Monitoring of Clinical Trials

Fundamentals for Investigators

(Autor)

Buch | Softcover
254 Seiten
2005
Springer-Verlag New York Inc.
978-0-387-27781-3 (ISBN)
CHF 74,85 inkl. MwSt
Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. The use of monitoring clinical trials is introduced in the context of the evolution of clinical research and one chapter is devoted to the more recent Bayesian procedures.
Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. Clearly presenting the necessary background with limited use of mathematics, this book increases the knowledge, experience, and intuition of investigations in the use of these important procedures now required by the many clinical research efforts.


The author provides motivated clinical investigators the background, correct use, and interpretation of these monitoring procedures at an elementary statistical level. He defines terms commonly used such as group sequential procedures and stochastic curtailment in non-mathematical language and discusses the commonly used procedures of Pocock, O’Brien–Fleming, and Lan–DeMets. He discusses the notions of conditional power, monitoring for safety and futility, and monitoring multiple endpoints in the study. The use of monitoring clinical trials is introduced in the context of the evolution of clinical research and one chapter is devoted to the more recent Bayesian procedures.


From the reviews:


"The author has a wealth of experience in this area and this is demonstrated throughout the text with relevant poignant examples." Short Book Reviews of the ISI, June 2006

Here, There be dragons….- The Basis of Statistical Reasoning in Medicine.- Probability Tools for Monitoring Rules.- Issues and Intuition in Path Analysis.- Group Sequential Analysis Procedures.- Looking Forward: Conditional Power.- Safety and Futility.- Bayesian Statistical Monitoring.

Zusatzinfo XXII, 254 p.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Sachbuch/Ratgeber Gesundheit / Leben / Psychologie Alternative Heilverfahren
Mathematik / Informatik Mathematik Statistik
Mathematik / Informatik Mathematik Wahrscheinlichkeit / Kombinatorik
Studium Querschnittsbereiche Epidemiologie / Med. Biometrie
Naturwissenschaften Biologie Humanbiologie
ISBN-10 0-387-27781-1 / 0387277811
ISBN-13 978-0-387-27781-3 / 9780387277813
Zustand Neuware
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