Principles of Molecular Medicine
Humana Press Inc. (Verlag)
978-0-89603-529-4 (ISBN)
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This is the first major textbook of molecular medicine to integrate the newest findings from cell and molecular biology with the basic principles of internal medicine. J. Larry Jameson, MD and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide array of disciplines - including neurology, cardiology, hematology, nephrology, genetics, endocrinology, oncology, dermatology, psychiatry, and infectious diseases - revealing the underlying molecular mechanisms of disease, as well as the routes to unprecedented novel medicines and treatments now emerging from the new molecular approaches. Here physicians will find informative updates in both their own specialties and in disciplines they may not have been able to follow closely. They will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.
This groundbreaking and uniquely valuable new approach to human medical biology will provide practicing physicians, medical students, and researchers alike with a powerful new account of internal medicine and help them to better understand the future of medicine.
Part I. Introduction To Molecular Medicine Andrea Ballabio and J. Larry Jameson . Organization of the Human Genome Chromosomes and Genes Sarah H. Elsea and Pragna I. Patel. Recombinant DNA and Genetic Techniques Marcus Grompe Wade Johnson and J. Larry Jameson. Transcriptional Control of Gene Expression Wade Johnson and J. Larry Jameson. Transmission of Human Genetic Disease Peter Kopp and J. Larry Jameson. The Human Genome Project J. Larry Jameson. The Cell Cycle Lynda Q. Nguyen and J. Larry Jameson. Oncogenes and Tumor Suppressor Genes J. Larry Jameson. Molecular Diagnostic Testing C. Sue Richards and Patricia A. Ward. Genetic Counseling Beth A. Fine. Transgenic Mice as Models of Disease T. Rajendra Kumar and Martin M. Matzuk. Part II. Cardiology Anthony Rosenzweig. Molecular Cardiology: An Overview Anthony Rosenzweig. Congenital Heart Disease: Inherited Cardiomyopathies Christine E. Seidman Calum MacRae and J. G. Seidman. Coronary Atherosclerosis Robert E. Gerszten and Anthony Rosenzweig. Endothelium-Derived Nitric Oxide and Control of Vascular Tone Santiago Lamas and Thomas Michel. Hypertension George Koike and Howard J. Jacob. Cardiac Arrhythmias Barry London. Cardiovascular Gene Therapy Giuseppe Vassalli and David A. Dichek. Part II. Hematology Swee Lay Thein. Hematopoiesis: Growth Factors and Mechanisms of Regulation Andrew Haynes and Nigel Russell. Disorders of Hemoglobin Structure and Synthesis Swee Lay Thein and Jacques Rochette.Disorders of the Red Cell Membrane Jean Delaunay. Red Cell Enzymopathies Lucio Luzzatto and Rosario Notaro. Coagulation Disorders Martina Daly Anne Goodeve Peter Winship and Ian Peake. Thrombotic Disorders Robin J. Olds David A. Lane and Swee Lay Thein. Paroxysomal Nocuturnal Hemoglobinuria Bruno Rotoli and Khedoudja Nafa. Leukemias Jeffrey E. Rubnitz and Ching-Hon Pui . Lymphomas Finbarr E. Cotter . Part IV. Immnology Ralph C. Williams Jr. Regulation of Humoral Immunity Ralph C. Williams Jr. Molecular Regulation of Cellular Immunity Eric Sobel. Cytokines William L. Lowe Jr. and Barbara A. da Silva. The HLA Complex Robert W. Karr. Inherited Immune Deficiency Richard Hong. Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (AIDS) John W. Sleasman and Maureen M. Goodenow. Autoimmune Diseases N. Lawrence Edwards.Allergic Diseases: Asthma as a Model Susan M. MacDonald. Part V. Pulmonolgy Michael J. Holtzman. Asthma Michael J. Holtzman Dwight C. Look Michael F. Iademarco Douglas C. Dean Deepak Sampath and Mario Castro. Cystic Fibrosis Daniel B. Rosenbluth and Steven L. Brody. Pulmonary Emphysema Steven D. Shapiro and Robert M. Senior Surfactant Deficiency Jeffrey A. Whitsett and Timothy E. Weaver. Lung Cancer: The Role of Tumor Suppressor Genes Steven Jay Weintraub. Part VI. Gastroenterology James C. Reynolds. Hepatology Piet C. de Groen and Nicholas F. LaRusso. Inherited Liver Disease Juan Ruiz and George Y. Wu.Viral Hepatitis and Liver Disease Sanjeev Gupta and Michael Ott. Pancreatic Exocrine Dysfunction David Whitcomb and Jonathan Cohn. Small- and Large-Bowel Dysfunction Deborah C. Rubin. Part VII. Endrocrinology Michael J. McPhaul md and J. Larry Jameson. Mechanisms of Hormone Action William L. Lowe Jr. Richard G. Pestell Laird D. Madison and J. Larry Jameson. Diabetes Mellitus William L. Lowe Jr. Pituitary Function and Neoplasia Shlomo Melmed. Growth Hormone Deficiency Disorders Joy D. Cogan and John A. Phillips III. Thyroid Disorders Peter Kopp and J. Larry Jameson. Disorders of the Parathyroid Gland Andrew Arnold and Andrew F. Stewart. Congenital Adrenal Hyperplasia Robert C. Wilson and Maria I. New. Adrenal Diseases Constantine A. Stratakis and George P. Chrousos. Multiple Endocrine Neoplasia Type 2 Robert F. Gagel Sarah Shefelbine and Gilbert Cote. Molecular Mechanisms of Hypoglycemia Associated with Increased Insulin Production Pamela M. Thomas Gilbert J. Cote and Robert F. Gagel. Regulation of Reproduction Michael J. McPhaul. Disorders of Sex Determination and Differentiation Charmian A. Quigley. Sex Chromosome Disorders Andrew R. Zinn. Disorders of Pubertal Development Karen D. Bradshaw and Charmian A. Quigley. Defects of Androgen Action Michael J. McPhaul. Testicular Diseases Marco Marcelli. Ovarian Diseases Elizabeth A. McGee and Nicholas A. Cataldo. Breast Cancer Melora D. Berardo D. Craig Allred and Peter O'Connell. Part VIII. Nephrology. Dennis Ausiello. Renal Development Vikas P. Sukhatme. Mechanisms of Leukocyte Extravasation M. Amin Arnaout. Ischemic Acute Renal Failure Joseph V. Bonventre. Potassium Secretory Channels in the Kidney Steven C. Hebert. Alport Syndrome Karl Tryggvason and Pirkko Heikkil". Nephrogenic Diabetes Insipidus Dennis Brown and Dennis A. Ausiello. Polycystic Kidney Disease Gregory G. Germino and Luiz F. Onuchic. Renal Neoplasms: Wilms' Tumor and Renal-Cell Carcinoma Kim E. Nichols and Daniel A. Haber. Part IX. DermatologyThomasS. Kupper. Congenital Diseases of Cutaneous Tissues. Selected Epidermal Gene Mutations. Introduction to Selected Epidermal Gene Mutations Angela M. Christiano Daniel B. Dubin and Thomas S. Kupper. Epidermolysis Bullosa SimplexYiu-mo Chan and Elaine Fuchs. Epidermolytic Hyperkeratosis John J. DiGiovanna Sherri J. Bale and Peter M. Steinert. Mosaicism and Epidermal Nevi Amy S. Paller. Darier's Disease and Hailey-Hailey Disease Lowell A. Goldsmith and Ervin Epstein Jr. Junctional Forms of Epidermolysis Bullosa Angela M. Christiano and Jouni Uitto. The Dystrophic Forms of Epidermolysis Bullosa Jouni Uitto and Angela M. Christiano . Genetic Mutations that Predispose to Cancer. Oculocutaneous Albinism Jean L. Bolognia. Basal Cell Nevus Syndrome Ervin Epstein Jr. Xeroderma Pigmentosa and Related Disorders W. Clark Lambert Hon-Reen Kuo and Muriel W. Lambert. The Skin as a Vehicle for Gene Therapy Soosan Ghazizadeh Tadeusz M. Kolodka and Lorne B. Taichman. Acquired Diseases of Cutaneous Tissues. Acquired Diseases of Cutaneous Tissues: Introduction Thomas S. Kupper. Basal- and Squamous-Cell Carcinoma Paul Nghiem and Thomas S. Kupper. Melanoma Genetics Daniel B. Dubin and Saumyen Sarkar. Psoriasis James T. Elder and John J. Voorhees. Atopic Dermatitis and Atopy Donald Y. M. Leung and Larry Borish. Pemphigus Foliaceus and Pemphigus Vulgaris Janet A. Fairley Xiang Ding George J. Giudice and Luis A. Diaz. Bullous Pemphigoid Cicatrical Pemphigoid and Pemphigoid Gestationis Grant J. Anhalt and Diya F. Mutasim. Cutaneous Lupus Erythematosus Richard D. Sontheimer. Scleroderma (Systemic Sclerosis) and Morphea Edwin A. Smith and E. Carwile LeRoy. Part X. Musculoskeletal Laurence Kedes. Muscle Development and Differentiation Eric N. Olson. Skeletal Muscle Structure and Function Henry F. Epstein. Muscular Dystrophies Eric P. Hoffman. Rhabdomyosarcomas Stephen J. Tapscott. Part XI. Neurology Joseph B. Martin. Molecular Neurobiology Joseph B. Martin and Frank M. Longo. Huntington's Disease Marcy E. MacDonald. Molecular Genetics of Alzheimer's Disease P. H. St. George-Hyslop. Amyotropic Lateral Sclerosis and Related Motor Neuron Diseases Meret E. Cudkowicz and Robert H. Brown Jr. Spinocerebellar Ataxia and Other Disorders of Trinucleotide Repeats Huda Y. Zoghbi. Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies James R. Lupski. Molecular and Genetic Basis of Prion Diseases Stanley B. Prusiner. Genetic Basis of Mitochondrial Disease Donald R. Johns. Malignant Hyperthermia and Central Core Disease David H. MacLennan and Beverley A. Britt. Retinoblastoma: A Current Review Joan M. O'Brien. Neurofibromatosis: Type 1 and Type 2 Jaime O. Claudio and Guy A. Rouleau. Brain Tumors Mark A. Israel. Part XII. Psychiatry Charles B. Nemeroff. Molecular Mechanisms and Regulating Behavior Paul M. Plotsky and Charles B. Nemeroff. Schizophrenia Ming T. Tsuang and Stephen V. Faraone. Affective Disorders Francis J. McMahon and J. Raymond DePaulo Jr. Alcoholism Eric J. Devor and Arthur Falek. Part XIII. Genetic Basis of Congentical Malformations Ethylin Wang Jabs. Waardenburg Syndrome Andrew P. Read. Greig Cephalopolysyndactyly Syndrome and Limb Disorders Karl-Heinz Grzeschik. Fibroblast Growth Factor Receptor-Related Skeletal Disorders: Craniosynostosis and Dwarfism Syndromes Maximilian Muenke Clair A. Francomano M. Michael Cohen Jr. and Ethylin Wang Jabs. Aarskog-Scott Syndrome Jerome L. Gorski. Beckwith-Wiedemann Syndrome Ellen R. Elias Michael R. DeBaun and Andrew P. Feinberg. Prader-Willi and Angelman Syndromes Robert D. Nicholls. Fragile X Syndrome David L. Nelson. Down Syndrome Stylianos E. Antonarakis. The 22q11 Deletion: DiGeorge and Velocardiofacial Syndrome Deborah A. Driscoll and Beverly S. Emanuel. Orofacial Clefting Jacqueline T. Hecht and Susan H. Blanton. Molecular Genetics of Hearing Disorders William J. Kimberling. Index.
| Verlagsort | Totowa, NJ |
|---|---|
| Sprache | englisch |
| Maße | 280 x 216 mm |
| Gewicht | 2859 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 0-89603-529-8 / 0896035298 |
| ISBN-13 | 978-0-89603-529-4 / 9780896035294 |
| Zustand | Neuware |
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