Brave Genomes

Microbial Genome Plasticity in the Face of Environmental Challenge

Silvia Bulgheresi (Autor)

Buch | Softcover

220 Seiten

2025
Academic Press Inc (Verlag)
978-0-443-18789-6 (ISBN)

Noch nicht erschienen (ca. Februar 2025)
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The role of environmentally triggered genetic and epigenetic changes in microbial adaptation and evolution is still not broadly appreciated. Brave Genomes: Microbial Genome Plasticity in the Face of Environmental Challenge narrates how microorganisms cope with environmental changes including unanticipated ones. Although it does comprise eukaryotes, it focuses on bacteria and – whenever possible – on archaea.

Among the environmentally sensitive sources of genome plasticity, the book treats tandem repeats, mutagenic break repair, transcription-associated mutagenesis and transposable elements. Additionally, it deals with epigenetic mechanisms such as DNA methylation and regulatory RNA-based systems. These not only regulate the activity of mobile DNA, they can also synergize with it. In closing, symbiosis and genetic noise are also discussed as possible sources of phenotypic plasticity.

Brave Genomes emphasizes the role of the environment in generating genotypic and phenotypic diversity. This emerges, in turn, as the most efficient response to challenging conditions.

Silvia Bulgheresi is Associate Professor in Environmental Cell Biology and independent researcher at the University of Vienna. Her research on the molecular mechanisms underlying symbiont growth, division and chromosome segregation challenged long-established bacterial cell biology tenets. Since 2008, she has been teaching environmental cell biology, microbial symbioses, as well as microbial genome plasticity to Bachelor, Master ad PhD students. It is in the effort of collecting the notes, thoughts and students’ questions that arose over two decades that this book was born.

1. DNA main facts across the three domains of life
2. DNA fun facts: how, when and where it may change a bit
3. Bacterial and archaeal DNA very fun facts: how, when and where it may change a lot
4. On top of the DNA and beyond
5. Biophyisical sources of phenotypic heterogeneity in bacteria
6. The microbes and the host epigenome (and vice versa)

Erscheint lt. Verlag	24.2.2025
Reihe/Serie	Progress in Biochemistry and Biotechnology
Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	450 g
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	0-443-18789-4 / 0443187894
ISBN-13	978-0-443-18789-6 / 9780443187896
Zustand	Neuware