Mass Spectrometry for Lipidomics (eBook)

Methods and Applications

Michal Holcapek, Kim Ekroos (Herausgeber)

eBook Download: EPUB

2023 | 1. Auflage
752 Seiten
Wiley-VCH GmbH (Verlag)
978-3-527-83650-5 (ISBN)

Infos

This systematic overview of lipidomic analysis by the president and vice president of the Lipidomics Society covers international standards of lipid analysis, available technology, key lipid classes, as well as applications in basic research, medicine, pharma and food industry.

Autor

Michal Holcapek obtained his Ph.D. at the University of Pardubice (Czech Republic), where he is now a full professor of analytical chemistry. His research focus is mass spectrometry and its coupling with liquid chromatography and supercritical fluid chromatography, applied mainly in the lipidomic analysis and cancer biomarker research. He is a coauthor of over 130 papers in peer-reviewed international journals, editor of 'Trends in Analytical Chemistry', and a member of the editorial advisory boards of 'Analytical and Bioanalytical Chemistry' and 'Lipids'. He is one of founding members of the Lipidomics Standards Initiative and the International Lipidomics Society, where he is on the position of vice-president. Kim Ekroos is the founder and CEO of Lipidomics Consulting Ltd. He received his Ph.D. degree in biology from the Technical University in Dresden (Germany). His expertise includes high-throughput technologies for the precise assessment of lipidomes enabled by advanced mass spectrometry, automation, and software tools for the discovery of biological architectures and of diagnostic biomarkers for clinical purpose. He is one of the pioneers in the field of lipidomics, with more than 20 years of experience in the academic, industry and regulatory aspects of lipidomics and lipid biology. He is a co-founder of the Lipidomics Standards Initiative (LSI) and the current president of the International Lipidomics Society.

Inhalt

Introduction to Lipidomics

ANALYTICAL METHODOLOGIES IN LIPIDOMICS
Preanalytics for Lipidomic Analysis
Direct Infusion (Shotgun) Electrospray Mass Spectrometry
Liquid Chromatography- and Supercritical Fluid Chromatography-Mass Spectrometry
Mass Spectrometry Imaging of Lipids
Ion Mobility Spectrometry
Structural Characterization of Lipids Using Advanced Mass Spectrometry Approaches
Lipidomic Identification
Lipidomic Quantitation
The Past and Future of Lipidomics Bioinformatics

LIPIDOMIC ANALYSIS ACCORDING TO LIPID CATEGORIES AND CLASSES
Fatty Acids: Structural and Quantitative Analysis
Quantitation of Oxylipins in Biological Samples
Mass Spectrometry for Analysis of Glycerolipids
Lipidomic Analysis of Glycerophospholipid Molecular Species in Biological Samples
Sphingolipids
Sterol Lipids
Bile Acids

LIPIDOMIC APPLICATIONS
Lipidomic Profiling in a Large-Scale Cohort
Cancer Lipidomics
Lipidomics in Clinical Diagnostics
Lipidomics in Food Industry and Nutrition
Lipidomics in Plant Science
Lipidomics in Multi-omics Studies
Tracer Lipidomics
Aging and Alzheimer?s Disease
Lipidomics in Cell Biology
Microbial Lipidomics

Produkt-Details

• Erscheint lt. Verlag: 7.3.2023
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Bioanalytical Chemistry • Bioanalytische Chemie • Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Chemie • Chemistry • Clinical Chemistry • Klinische Chemie • Massenspektrometrie • Mass Spectrometry • Medical Science • Medizin
• ISBN-10: 3-527-83650-0 / 3527836500
• ISBN-13: 978-3-527-83650-5 / 9783527836505