Pathophysiology of Lysosomal Transport
Crc Press Inc (Verlag)
978-0-8493-6724-3 (ISBN)
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The field of lysosomal transport has grown exponentially in the past decade. Research in this previously unknown function of lysosomes has resulted in understanding the metabolic defect in three inborn errors in metabolism: nephropathic cystinosis, cobalamin F-deficient methylmalonic aciduria, and Salla disease. Seventeen transport systems mediating the exodus from lysosomes of amino acids, sugars, nucleosides, phosphate, calcium, cobalamin, and sulfate have been described.
Pathophysiology of Lysosomal Transport presents the current status in this field as described by the authors who made the original discoveries. Each chapter examines the pathological consequences resulting from a defect in a particular system. The book also examines the transfer of macromolecules into the lysosomes, describes the analogy between mammalian lysosomes and vacuoles of plants and fungi, and reviews non-mediated transport. A comprehensive chapter on the methodology required to perform lysosomal studies will benefit researchers undertaking investigations in this area.
INTRODUCTION (Jess Thoene). APPROACHES TO THE STUDY OF LYSOSOMAL TRANSPORT (Alice Greene and Jerry Schneider). LYSOSOMAL TRANSPORT OF AMINO ACIDS. Lysosomal Cystine Transport (William Gahl). Lysosomal Transport of Small and Large Neutral Amino Acids (Hans Andersson). Lysosomal Transport Systems for Cationic and Anionic Amino Acids: Systems c and d (Ronald Pisoni). LYSOSOMAL TRANSPORT OF INORGANIC IONS. The Transport of Phosphate and Calcium by Human Fibroblast Lysosomes (Ronald Pisoni and Jess Thoene). Lysosomal Sulfate Transport (Jaydutt Vadgama and Adam Jonas). LYSOSOMAL TRANSPORT OF OTHER METABOLITES. Lysosomal Nucleic Acid Catabolism and Carrier Mediated Transport of Nucleosides (Ronald Pisoni and Jess Thoene). Lysosomal Transport of Sugars: Normal and Pathological (Frank Tietze). Lysosomal Cobalamin Transport (Susan Sillaots and David Rosenblatt). TRANSPORT OF MACROMOLECULES TO LYSOSOMES (Hsiang-Kuang Lee and Louis Marzella). PASSIVE DIFFUSION ACROSS THE LYSOSOME MEMBRANE (John Lloyd). VACUOLES OF PLANTS AND FUNGI (John-Michael Idriss).
| Erscheint lt. Verlag | 12.5.1992 |
|---|---|
| Zusatzinfo | 26 Tables, black and white |
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 235 mm |
| Gewicht | 680 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 0-8493-6724-7 / 0849367247 |
| ISBN-13 | 978-0-8493-6724-3 / 9780849367243 |
| Zustand | Neuware |
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