Particle Overload In The Rat Lung And Lung Cancer
Taylor & Francis Inc (Verlag)
978-1-56032-543-7 (ISBN)
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Recent inhalation toxicology studies suggest that when laboratory rats are exposed to inorganic particles to the point that lung overload occurs, both benign and malignant tumours may develop. The significance of these results for estimating human risk, however, is unclear.; Originally published as a special issue of the journal "Inhalation Toxicology", the contributions to this volume are derived from a symposium held in March, 1995, by the Environmental Medical Service of the Massachusetts Institute of Technology. Topics addressed include epidemiology, the pathology of lung tumours, maximum tolerated doses in inhalation toxicology studies, risk assessment, the extrapolation of results from animal studies to humans, current modelling techniques and regulatory concerns.
Lung overload - the dilemma and opportunities for resolution; from the lab bench to the workplace - implications of toxicology studies on occupational medical practice; epidemiological studies in North American carbon black workers; comparative response to long-term particle exposure among rats, mice and hamsters; significance of particle parameters in the evaluation of exposure-dose-response; relationships of inhaled particles; current information on lung overload in non-rodent mammals; maximum tolerated dose in particulate inhalation studies - a pathologist's point of view; differences between rodents and humans in lung tumor response - lessons from recent studies with carbon black; role of inflammation in the development of rat lung tumors in response to chronic particle exposure; evalution of the carcinogenic risk of biochemically inert insoluble particles by the EPA using rat inhalation data; use of hazard and risk information in risk management decisions - solid particles and fibres under EPA's TSUSAU and EPCRA; lung cancer in rats from prolonged exposure to high concentrates of particles - implications for human risk assessment.
| Erscheint lt. Verlag | 3.6.1996 |
|---|---|
| Verlagsort | Washington |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 708 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Veterinärmedizin ► Klinische Fächer ► Versuchstiere | |
| ISBN-10 | 1-56032-543-7 / 1560325437 |
| ISBN-13 | 978-1-56032-543-7 / 9781560325437 |
| Zustand | Neuware |
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